Efficacy of two novel 2,2'-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin

The therapeutic efficacy of two novel bifurans and vancomycin in an animal model of a methicillin-resistant Staphylococcus aureus (MRSA) infection was compared. Adult male CF-1 mice (25-35 g) were intraperitoneally injected with 200 μL/mouse containing 10(7) cell-forming units of MRSA. After 16 hour...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2012, Vol.6, p.279-287
Hauptverfasser:	El-Sayed, Wael M, Hussin, Warda A, Ismail, Mohamed A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animal models Animals Anti-Bacterial Agents - therapeutic use Antibiotics antioxidants Bacterial infections bifuran derivatives Catalase Ciprofloxacin Comparative analysis Control Drug resistance Drug therapy Effectiveness Furans Furans - therapeutic use Glutathione Glutathione - metabolism glutathione system Glutathione transferase Infections Interleukin 6 Kidneys Lipid Peroxidation - drug effects Liver Male Malondialdehyde Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Mice MRSA Original Research Pathogenesis septicemia Serum levels Spleen Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus infections Toxicity Urea Vancomycin Vancomycin - therapeutic use γ-Glutamyltransferase
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