Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

Myosin VI is the only known reverse-direction myosin motor. It has an unprecedented means of amplifying movements within the motor involving rearrangements of the converter subdomain at the C terminus of the motor and an unusual lever arm projecting from the converter. While the average step size of...

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Veröffentlicht in:	Molecular cell 2012-10, Vol.48 (1), p.75-86
Hauptverfasser:	Ménétrey, Julie, Isabet, Tatiana, Ropars, Virginie, Mukherjea, Monalisa, Pylypenko, Olena, Liu, Xiaoyan, Perez, Javier, Vachette, Patrice, Sweeney, H. Lee, Houdusse, Anne M.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - chemistry Actins - metabolism Animals Binding Sites Biophysical Phenomena Calmodulin - chemistry Calmodulin - metabolism Compliance Crystallography, X-Ray kinesin Life Sciences Models, Biological Models, Molecular Molecular Motor Proteins - chemistry Molecular Motor Proteins - metabolism Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism myosin Myosin Heavy Chains - chemistry Myosin Heavy Chains - metabolism Myosins - chemistry Myosins - metabolism Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Conformation Protein Multimerization Protein Structure, Quaternary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Swine
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