Focal cerebral ischemia and mitochondrial dysfunction in the TNFα-transgenic rat

Abstract Post-ischemic neurodegeneration may be accelerated by a cytokine-receptor mediated apoptotic pathway, as shown in a transgenic rat overexpressing tumor necrosis factor-alpha (TNFα) in brain. To further investigate the mechanism of ischemic cellular injury in this animal, we tested the hypot...

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Veröffentlicht in:	Brain research 2011-04, Vol.1384, p.151-160
Hauptverfasser:	Pandya, Jignesh D, Sullivan, Patrick G, Pettigrew, L. Creed
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Analysis of Variance Animals Animals, Genetically Modified Apoptosis ATP Biological and medical sciences Blood Glucose Brain Brain ischemia Brain Ischemia - genetics calcium Calcium (mitochondrial) Calcium - metabolism Calcium homeostasis Cerebral blood flow Cerebral Cortex - pathology Cerebral Cortex - ultrastructure Cytokines death Electron Transport - genetics Electron Transport - physiology Energy Metabolism - genetics gene overexpression genetically modified organisms Inflammation Injuries Ischemia Medical sciences Membrane permeability mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial bioenergetics Mitochondrial Diseases - genetics Mitochondrial permeability transition pore NAD - metabolism Neurodegeneration Neurology Oxidative stress Rats Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion Respiration Transgenic rat Tumor necrosis factor alpha Tumor Necrosis Factor-alpha - genetics Vascular diseases and vascular malformations of the nervous system
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