Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

Both neuroprotective and neurotoxic roles have previously been described for histone deacetylase-1 (HDAC1). Here we report that HDAC1 expression is elevated in vulnerable brain regions of two mouse models of neurodegeneration, the R6/2 model of Huntington disease and the Ca2+/calmodulin-dependent pr...

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Veröffentlicht in:	The Journal of biological chemistry 2012-10, Vol.287 (42), p.35444-35453
Hauptverfasser:	Bardai, Farah H., Price, Valerie, Zaayman, Marcus, Wang, Lulu, D'Mello, Santosh R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt PKB Animals Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Cycle Cell Death - genetics Cerebellar Cortex - enzymology Cerebellar Cortex - pathology Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta HDAC1 HDAC3 HDRP Histone Deacetylase Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Mice Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurobiology Neurodegeneration Neuronal Survival Neurons Neurons - enzymology Neurons - pathology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Tauopathies - enzymology Tauopathies - genetics Tauopathies - pathology
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