Chondro/osteoblastic and cardiovascular gene modulation in human artery smooth muscle cells that calcify in the presence of phosphate and calcitriol or paricalcitol

Vitamin D sterol administration, a traditional treatment for secondary hyperparathyroidism, may increase serum calcium and phosphorus, and has been associated with increased vascular calcification (VC). In vitro studies suggest that in the presence of uremic concentrations of phosphorus, vitamin D s...

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Veröffentlicht in:	Journal of cellular biochemistry 2010-11, Vol.111 (4), p.911-921
Hauptverfasser:	Shalhoub, V., Shatzen, E.M., Ward, S.C., Young, J-I., Boedigheimer, M., Twehues, L., McNinch, J., Scully, S., Twomey, B., Baker, D., Kiaei, P., Damore, M.A., Pan, Z., Haas, K., Martin, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone morphogenetic protein 6 Branched DNA Signal Amplification Assay Calcification Calcification (ectopic) Calcification, Physiologic - drug effects Calcification, Physiologic - genetics Calcitriol Calcitriol - pharmacology Cardiovascular diseases Cell cycle Cell Differentiation - drug effects Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Colorimetry coronary artery Coronary Vessels - cytology Culture Media - pharmacology Dkk1 protein Ergocalciferols - pharmacology Gene expression Gene Expression Regulation - drug effects Humans Mineralization Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Oligonucleotide Array Sequence Analysis Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoprotegerin Phosphate Phosphates - pharmacology Phosphorus Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism Reproducibility of Results Response Elements - genetics Smooth muscle Sterols Tissue Donors Vitamin D Vitamin D - genetics
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