Cell cholesterol modulates metalloproteinase‐dependent shedding of low‐density lipoprotein receptor‐related protein‐1 (LRP‐1) and clearance function

ABSTRACT Low‐density lipoprotein receptor‐related protein‐1 (LRP‐1) is a plasma membrane scavenger and signaling receptor, composed of a large ligand‐binding subunit (515‐kDa α‐chain) linked to a shorter transmembrane subunit (85‐kDa β‐chain). LRP‐1 cell‐surface level and function are controlled by...

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Veröffentlicht in:	The FASEB journal 2011-08, Vol.25 (8), p.2770-2781
Hauptverfasser:	Selvais, Charlotte, D'Auria, Ludovic, Tyteca, Donatienne, Perrot, Gwenn, Lemoine, Pascale, Troeberg, Linda, Dedieu, Stéphane, Noël, Agne's, Nagase, Hideaki, Henriet, Patrick, Courtoy, Pierre J., Marbaix, Etienne, Emonard, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAM Proteins - antagonists & inhibitors ADAM Proteins - genetics ADAM Proteins - metabolism ADAM12 Protein Antigens, CD - chemistry Antigens, CD - metabolism Base Sequence Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Cell Line, Tumor Cell Membrane - metabolism Cholesterol - metabolism endocytosis Epithelioid Cells - metabolism Fibroblasts - metabolism Humans Life sciences Low Density Lipoprotein Receptor-Related Protein-1 - chemistry Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Metalloproteases - metabolism MMP plasma membrane Protein Structure, Tertiary raft Research Communications RNA, Small Interfering - genetics Sciences du vivant Signal Transduction
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