E2FBP1 antagonizes the p16INK4A-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability

Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16INK4A and promyelocytic leukemia protein （PML） in normal cells. E2F-binding protein 1 （E2FBP1）, a transcrip...

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Veröffentlicht in:	International journal of oral science 2011-10, Vol.3 (4), p.200-208
Hauptverfasser:	Fukuyo, Yayoi, Takahashi, Akiko, Hara, Eiji, Horikoshi, Nobuo, Pandita, Tej K, Nakajima, Takuma
Format:	Artikel
Sprache:	eng
Schlagworte:	Dentistry Medicine Oral and Maxillofacial Surgery Original original-article Orthopedics Surgical Orthopedics 拮抗剂 生长抑制 白血病 稳定性 粒细胞 细胞衰老 结合蛋白 肿瘤抑制
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