Endosulfan induced early pathological changes in vital organs of rat: a biochemical approach
To evaluate the pathogenesis in heart and liver by the early induction of biochemical and antioxidant derangements in rats exposed to endosulfan. Wistar rats were gavaged with endosulfan (0.5, 1 and 1.5 mg/kg body weight in sunflower oil) for a period of 21 days (single dose at 24 h interval). Contr...
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| Veröffentlicht in: | Indian journal of pharmacology 2012-07, Vol.44 (4), p.512-515 |
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| creator | Alva, Sathyavathi Damodar, D D'Souza, Antony D'Souza, Urban J A |
| description | To evaluate the pathogenesis in heart and liver by the early induction of biochemical and antioxidant derangements in rats exposed to endosulfan.
Wistar rats were gavaged with endosulfan (0.5, 1 and 1.5 mg/kg body weight in sunflower oil) for a period of 21 days (single dose at 24 h interval). Control and sunflower oil control groups were also maintained simultaneously. Rats were sacrificed on the 22(nd) day posttreatment. Blood samples, heart and liver were collected and different biochemical parameters such as total protein, cholesterol, triglycerides, amino acids and antioxidant and lipid peroxidation level were measured. Statistical analysis was carried out by one way ANOVA, followed by Bonferroni' post-hoc test.
Endosulfan induced a significant increase in the serum levels of total protein, amino acids, triglyceride, total cholesterol, free fatty acid and phospholipid levels in a dose-dependent manner. In the heart and liver, lipid peroxidation was increased significantly in a dose-dependent manner and the antioxidant levels such as superoxide dismutase (SOD), glutathione S-transferase, glutathione peroxidase, and catalase were significantly decreased in a dose-dependent pattern.
Exposure to endosulfan results in a significant derangement in the biochemical parameters with a decrease in antioxidant levels in the heart and liver. This is an early indication of pathogenesis in the vital organs of rats. |
| doi_str_mv | 10.4103/0253-7613.99335 |
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Wistar rats were gavaged with endosulfan (0.5, 1 and 1.5 mg/kg body weight in sunflower oil) for a period of 21 days (single dose at 24 h interval). Control and sunflower oil control groups were also maintained simultaneously. Rats were sacrificed on the 22(nd) day posttreatment. Blood samples, heart and liver were collected and different biochemical parameters such as total protein, cholesterol, triglycerides, amino acids and antioxidant and lipid peroxidation level were measured. Statistical analysis was carried out by one way ANOVA, followed by Bonferroni' post-hoc test.
Endosulfan induced a significant increase in the serum levels of total protein, amino acids, triglyceride, total cholesterol, free fatty acid and phospholipid levels in a dose-dependent manner. In the heart and liver, lipid peroxidation was increased significantly in a dose-dependent manner and the antioxidant levels such as superoxide dismutase (SOD), glutathione S-transferase, glutathione peroxidase, and catalase were significantly decreased in a dose-dependent pattern.
Exposure to endosulfan results in a significant derangement in the biochemical parameters with a decrease in antioxidant levels in the heart and liver. This is an early indication of pathogenesis in the vital organs of rats.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.99335</identifier><identifier>PMID: 23087516</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Animals ; Antioxidants - metabolism ; Biochemistry ; Body Weight - drug effects ; Body Weight - physiology ; Down-Regulation - drug effects ; Endosulfan ; Endosulfan - toxicity ; Health aspects ; Heart ; Heart - drug effects ; Heart - physiology ; Heart Diseases - blood ; Heart Diseases - chemically induced ; Heart Diseases - pathology ; Hepatitis, Animal - blood ; Hepatitis, Animal - chemically induced ; Hepatitis, Animal - pathology ; Insecticides - toxicity ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Male ; Myocardium - enzymology ; Myocardium - metabolism ; Myocardium - pathology ; Pathogenesis ; Pharmacology ; Physiological aspects ; Physiology, Pathological ; Rats ; Rats, Wistar ; Short Communication</subject><ispartof>Indian journal of pharmacology, 2012-07, Vol.44 (4), p.512-515</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jul/Aug 2012</rights><rights>Copyright: © Indian Journal of Pharmacology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-77ca446b58ed2a9bc13444b2d499338f18aaeedf236846406769b20e8f9c2eba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469958/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469958/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23087516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alva, Sathyavathi</creatorcontrib><creatorcontrib>Damodar, D</creatorcontrib><creatorcontrib>D'Souza, Antony</creatorcontrib><creatorcontrib>D'Souza, Urban J A</creatorcontrib><title>Endosulfan induced early pathological changes in vital organs of rat: a biochemical approach</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>To evaluate the pathogenesis in heart and liver by the early induction of biochemical and antioxidant derangements in rats exposed to endosulfan.
Wistar rats were gavaged with endosulfan (0.5, 1 and 1.5 mg/kg body weight in sunflower oil) for a period of 21 days (single dose at 24 h interval). Control and sunflower oil control groups were also maintained simultaneously. Rats were sacrificed on the 22(nd) day posttreatment. Blood samples, heart and liver were collected and different biochemical parameters such as total protein, cholesterol, triglycerides, amino acids and antioxidant and lipid peroxidation level were measured. Statistical analysis was carried out by one way ANOVA, followed by Bonferroni' post-hoc test.
Endosulfan induced a significant increase in the serum levels of total protein, amino acids, triglyceride, total cholesterol, free fatty acid and phospholipid levels in a dose-dependent manner. In the heart and liver, lipid peroxidation was increased significantly in a dose-dependent manner and the antioxidant levels such as superoxide dismutase (SOD), glutathione S-transferase, glutathione peroxidase, and catalase were significantly decreased in a dose-dependent pattern.
Exposure to endosulfan results in a significant derangement in the biochemical parameters with a decrease in antioxidant levels in the heart and liver. This is an early indication of pathogenesis in the vital organs of rats.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Down-Regulation - drug effects</subject><subject>Endosulfan</subject><subject>Endosulfan - toxicity</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - chemically induced</subject><subject>Heart Diseases - pathology</subject><subject>Hepatitis, Animal - blood</subject><subject>Hepatitis, Animal - chemically induced</subject><subject>Hepatitis, Animal - pathology</subject><subject>Insecticides - toxicity</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Myocardium - enzymology</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Pathogenesis</subject><subject>Pharmacology</subject><subject>Physiological aspects</subject><subject>Physiology, Pathological</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Short Communication</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1r3DAQhkVpaLZpz70VQ8_eWB-WpR4KISRpIJBLeyuIsSzZCl7JlexA_n3kJN0msOggNPPMO5oPhL7gastwRU8rUtOy4ZhupaS0foc2WEpR0qbG79Fm7z1GH1O6q_KbSf4BHRNaiYzwDfpz4buQltGCL5zvFm26wkAcH4oJ5iGMoXcaxkIP4HuTMlLcuzkbQuzBpyLYIsL8vYCidUEPZvdEwzTFAHr4hI4sjMl8frlP0O_Li1_nP8ub26vr87ObUteEz2XTaGCMt7UwHQHZakwZYy3p2FqUsFgAGNNZQrlgnFW84bIllRFWamJaoCfox7PutLQ702nj5wijmqLbQXxQAZx66_FuUH24V5RxKWuRBb69CMTwdzFpVndhiT7_WeUuMyoIE_w_1cNolPM2ZDG9c0mrMyKlrBohcKbKA1RvvMmZgzfWZfMbfnuAz6dbu3kw4PQ5QMeQUjR2Xyiu1LoVap27WueunrYiR3x93Z89_28N6CO2ebGJ</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Alva, Sathyavathi</creator><creator>Damodar, D</creator><creator>D'Souza, Antony</creator><creator>D'Souza, Urban J A</creator><general>Medknow Publications and Media Pvt. 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Wistar rats were gavaged with endosulfan (0.5, 1 and 1.5 mg/kg body weight in sunflower oil) for a period of 21 days (single dose at 24 h interval). Control and sunflower oil control groups were also maintained simultaneously. Rats were sacrificed on the 22(nd) day posttreatment. Blood samples, heart and liver were collected and different biochemical parameters such as total protein, cholesterol, triglycerides, amino acids and antioxidant and lipid peroxidation level were measured. Statistical analysis was carried out by one way ANOVA, followed by Bonferroni' post-hoc test.
Endosulfan induced a significant increase in the serum levels of total protein, amino acids, triglyceride, total cholesterol, free fatty acid and phospholipid levels in a dose-dependent manner. In the heart and liver, lipid peroxidation was increased significantly in a dose-dependent manner and the antioxidant levels such as superoxide dismutase (SOD), glutathione S-transferase, glutathione peroxidase, and catalase were significantly decreased in a dose-dependent pattern.
Exposure to endosulfan results in a significant derangement in the biochemical parameters with a decrease in antioxidant levels in the heart and liver. This is an early indication of pathogenesis in the vital organs of rats.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>23087516</pmid><doi>10.4103/0253-7613.99335</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of pharmacology, 2012-07, Vol.44 (4), p.512-515 |
| issn | 0253-7613 1998-3751 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antioxidants - metabolism Biochemistry Body Weight - drug effects Body Weight - physiology Down-Regulation - drug effects Endosulfan Endosulfan - toxicity Health aspects Heart Heart - drug effects Heart - physiology Heart Diseases - blood Heart Diseases - chemically induced Heart Diseases - pathology Hepatitis, Animal - blood Hepatitis, Animal - chemically induced Hepatitis, Animal - pathology Insecticides - toxicity Liver Liver - drug effects Liver - metabolism Liver - pathology Male Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Pathogenesis Pharmacology Physiological aspects Physiology, Pathological Rats Rats, Wistar Short Communication |
| title | Endosulfan induced early pathological changes in vital organs of rat: a biochemical approach |
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