The Seed Region of a Small RNA Drives the Controlled Destruction of the Target mRNA by the Endoribonuclease RNase E

Numerous small non-coding RNAs (sRNAs) in bacteria modulate rates of translation initiation and degradation of target mRNAs, which they recognize through base-pairing facilitated by the RNA chaperone Hfq. Recent evidence indicates that the ternary complex of Hfq, sRNA and mRNA guides endoribonucleas...

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Veröffentlicht in:	Molecular cell 2012-09, Vol.47 (6), p.943-953
Hauptverfasser:	Bandyra, Katarzyna J., Said, Nelly, Pfeiffer, Verena, Górna, Maria W., Vogel, Jörg, Luisi, Ben F.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Endoribonucleases - genetics Endoribonucleases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Host Factor 1 Protein - genetics Host Factor 1 Protein - metabolism messenger RNA non-coding RNA Porins - genetics ribonucleases RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Untranslated - genetics RNA, Small Untranslated - metabolism Salmonella - genetics Salmonella - metabolism translation (genetics)
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