SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH

Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents loss of mitochondrial membrane potential (Δ Ψ mt ), intracellular acidification and reactive oxygen speci...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death and differentiation 2012-11, Vol.19 (11), p.1815-1825
Hauptverfasser:	Pellegrini, L, Pucci, B, Villanova, L, Marino, M L, Marfe, G, Sansone, L, Vernucci, E, Bellizzi, D, Reali, V, Fini, M, Russo, M A, Tafani, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612 631/80/642/333 631/80/82 Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Biochemistry Biomedical and Life Sciences Carbonic Anhydrases - metabolism Cell Biology Cell Cycle Analysis Cell death Cell Hypoxia Cell Line, Tumor Enzyme Inhibitors - pharmacology HeLa Cells Hexokinase - metabolism Humans Hydrogen-Ion Concentration - drug effects K562 Cells Life Sciences Membrane Potential, Mitochondrial - drug effects Mitochondria - metabolism Original Paper Protein Binding Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism Sirtuin 3 - antagonists & inhibitors Sirtuin 3 - genetics Sirtuin 3 - metabolism Staurosporine - pharmacology Stem Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!