Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL

Although accumulating evidence has confirmed the important roles of thyroid hormone (T 3 ) and its receptors (TRs) in tumor progression, the specific functions of TRs in carcinogenesis remain unclear. In the present study, tumor necrosis factor (TNF)-related apoptosis-inducing ligand ( TRAIL ) was d...

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Veröffentlicht in:	Cell death and differentiation 2012-11, Vol.19 (11), p.1802-1814
Hauptverfasser:	Chi, H-C, Chen, S-L, Liao, C-J, Liao, C-H, Tsai, M-M, Lin, Y-H, Huang, Y-H, Yeh, C-T, Wu, S-M, Tseng, Y-H, Chen, C-Y, Tsai, C-Y, Chung, I-H, Chen, W-J, Lin, K-H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/82/23 631/80/86 692/420/755 692/699/67/1504/1610 Animals Apoptosis Apoptosis - drug effects bcl-X Protein - antagonists & inhibitors bcl-X Protein - genetics bcl-X Protein - metabolism Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Genes Hep G2 Cells Humans Kinases Life Sciences Ligands Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase 9 - metabolism Metastasis Mice Mice, SCID Neoplasm Metastasis Original Paper Proteins Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Stem Cells Thyroid gland TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Transcription factors Transplantation, Heterologous Triiodothyronine - pharmacology Tumor necrosis factor-TNF Tumorigenesis Up-Regulation - drug effects
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