Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity

Vascular smooth muscle responsiveness to nitric oxide, as assessed by nitroglycerin-induced dilation (NID), is impaired in clinical cardiovascular disease, but its relation to adiposity is unknown. We determined the relation of NID to total and abdominal adiposity in healthy adults varying widely in...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2012-09, Vol.303 (6), p.H743-H750
Hauptverfasser:	Christou, Demetra D, Pierce, Gary L, Walker, Ashley E, Hwang, Moon-Hyon, Yoo, Jeung-Ki, Luttrell, Meredith, Meade, Thomas H, English, Mark, Seals, Douglas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adiposity Administration, Sublingual Adolescent Adult Aged Blood pressure Body fat Body Mass Index Brachial Artery - drug effects Brachial Artery - metabolism Brachial Artery - physiopathology Cardiovascular disease Female Humans Integrative Cardiovascular Physiology and Pathophysiology Linear Models Male Middle Aged Multivariate Analysis Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - administration & dosage Nitroglycerin - administration & dosage Obesity, Abdominal - diagnosis Obesity, Abdominal - metabolism Obesity, Abdominal - physiopathology Risk Assessment Risk Factors Tomography Tomography, X-Ray Computed United States Vasodilation - drug effects Vasodilator Agents - administration & dosage Waist Circumference Waist-Hip Ratio Young Adult
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