Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men
Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men. A study of 109 randomly selected men in a university-based andrology laboratory was done. CK activity differed betwee...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 1999, Vol.16 (1), p.35-40 |
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| creator | GERGELY, A SZOLLOSI, J FALKAI, G RESCH, B KOVACS, L HUSZAR, G |
| description | Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men.
A study of 109 randomly selected men in a university-based andrology laboratory was done.
CK activity differed between normospermic and oligozospermic men (0.21 +/- 0.02 vs. 1.19 +/- 0.15 CK IU/10(8) sperm; n = 56 and n = 53; mean +/- standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = -0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 x 10(6) sperm/ml), whereas 36% of men in the group with 20-30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.
The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm. |
| doi_str_mv | 10.1023/A:1022545612784 |
| format | Article |
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A study of 109 randomly selected men in a university-based andrology laboratory was done.
CK activity differed between normospermic and oligozospermic men (0.21 +/- 0.02 vs. 1.19 +/- 0.15 CK IU/10(8) sperm; n = 56 and n = 53; mean +/- standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = -0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 x 10(6) sperm/ml), whereas 36% of men in the group with 20-30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.
The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1023/A:1022545612784</identifier><identifier>PMID: 9987692</identifier><identifier>CODEN: JARGE4</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Biological and medical sciences ; Biomarkers ; Couples ; Creatine Kinase - metabolism ; Cytoplasm ; Fertility ; Fundamental and applied biological sciences. Psychology ; Humans ; Hungary ; In vitro fertilization ; Infertility ; Kinases ; Male ; Mammalian male genital system ; Morphology. Physiology ; Motility ; Oligospermia - enzymology ; Semen - cytology ; Sperm ; Sperm Count ; Spermatozoa - enzymology ; Vertebrates: reproduction</subject><ispartof>Journal of assisted reproduction and genetics, 1999, Vol.16 (1), p.35-40</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Jan 1999</rights><rights>Plenum Publishing Corporation 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-b1ebb6c9137c0cd2f565532a11d367b34aae0d9a747f57089f2526893f8193753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468215/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468215/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1677738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9987692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GERGELY, A</creatorcontrib><creatorcontrib>SZOLLOSI, J</creatorcontrib><creatorcontrib>FALKAI, G</creatorcontrib><creatorcontrib>RESCH, B</creatorcontrib><creatorcontrib>KOVACS, L</creatorcontrib><creatorcontrib>HUSZAR, G</creatorcontrib><title>Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men.
A study of 109 randomly selected men in a university-based andrology laboratory was done.
CK activity differed between normospermic and oligozospermic men (0.21 +/- 0.02 vs. 1.19 +/- 0.15 CK IU/10(8) sperm; n = 56 and n = 53; mean +/- standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = -0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 x 10(6) sperm/ml), whereas 36% of men in the group with 20-30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.
The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Couples</subject><subject>Creatine Kinase - metabolism</subject><subject>Cytoplasm</subject><subject>Fertility</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hungary</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Kinases</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Morphology. Physiology</subject><subject>Motility</subject><subject>Oligospermia - enzymology</subject><subject>Semen - cytology</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Spermatozoa - enzymology</subject><subject>Vertebrates: reproduction</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1L5TAUxYM4-DlrV0IRcVcnyW2-XAgi4wcILsZZl9s0fUbb5Jm0gvPXT8XHQ13dyz0_DuceQg4YPWWUw6-Ls3lwUQnJuNLVBtlhQkGpAOjmvFOhS1pJvU12c36ilBrNYYtsGaOVNHyH3P9ZujQUNjkcfXDFsw-YXYF29K9-fCt8KEJMQ8zvmLcFhraIvV_Ef-vTzRQWmDyGYnBhn_zosM_u52rukb9Xvx8ub8q7--vby4u70la0GsuGuaaR1jBQltqWd0IKARwZa0GqBipER1uDqlKdUFSbjgsutYFOMwNKwB45__BdTs3gWuvCmLCvl8kPmN7qiL7-qgT_WC_iaw1zG5y9G5ysDFJ8mVwe68Fn6_oeg4tTrqURilPBZvDoG_gUpxTm52rOpGQgBczQ4ec46xyrnmf9eKVjtth3CYP1eY0xqZQCDf8BGi-Mtw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>GERGELY, A</creator><creator>SZOLLOSI, J</creator><creator>FALKAI, G</creator><creator>RESCH, B</creator><creator>KOVACS, L</creator><creator>HUSZAR, G</creator><general>Kluwer/Plenum</general><general>Springer Nature B.V</general><general>Kluwer Academic Publishers-Plenum Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>1999</creationdate><title>Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men</title><author>GERGELY, A ; SZOLLOSI, J ; FALKAI, G ; RESCH, B ; KOVACS, L ; HUSZAR, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-b1ebb6c9137c0cd2f565532a11d367b34aae0d9a747f57089f2526893f8193753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Couples</topic><topic>Creatine Kinase - metabolism</topic><topic>Cytoplasm</topic><topic>Fertility</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hungary</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Kinases</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Morphology. Physiology</topic><topic>Motility</topic><topic>Oligospermia - enzymology</topic><topic>Semen - cytology</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Spermatozoa - enzymology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GERGELY, A</creatorcontrib><creatorcontrib>SZOLLOSI, J</creatorcontrib><creatorcontrib>FALKAI, G</creatorcontrib><creatorcontrib>RESCH, B</creatorcontrib><creatorcontrib>KOVACS, L</creatorcontrib><creatorcontrib>HUSZAR, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GERGELY, A</au><au>SZOLLOSI, J</au><au>FALKAI, G</au><au>RESCH, B</au><au>KOVACS, L</au><au>HUSZAR, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>1999</date><risdate>1999</risdate><volume>16</volume><issue>1</issue><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><coden>JARGE4</coden><abstract>Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men.
A study of 109 randomly selected men in a university-based andrology laboratory was done.
CK activity differed between normospermic and oligozospermic men (0.21 +/- 0.02 vs. 1.19 +/- 0.15 CK IU/10(8) sperm; n = 56 and n = 53; mean +/- standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = -0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 x 10(6) sperm/ml), whereas 36% of men in the group with 20-30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.
The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>9987692</pmid><doi>10.1023/A:1022545612784</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biomarkers Couples Creatine Kinase - metabolism Cytoplasm Fertility Fundamental and applied biological sciences. Psychology Humans Hungary In vitro fertilization Infertility Kinases Male Mammalian male genital system Morphology. Physiology Motility Oligospermia - enzymology Semen - cytology Sperm Sperm Count Spermatozoa - enzymology Vertebrates: reproduction |
| title | Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men |
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