Hwangryun-Haedok-Tang Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss
Hwangryun-haedok-tang (HRT) is the common recipe in traditional Asian medicine, and microbial fermentation is used for the conventional methods for processing traditional medicine. We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-12 |
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| creator | Ma, Jin Yeul Kim, Han Sung Cho, Chang-Won Ha, Hyunil Kim, Taesoo Shim, Ki-Shuk Seo, Dong-Hyun |
| description | Hwangryun-haedok-tang (HRT) is the common recipe in traditional Asian medicine, and microbial fermentation is used for the conventional methods for processing traditional medicine. We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages. mRNA expression of osteoclastogenesis-related genes were evaluated by real-time QPCR. The activation of signaling pathways was determined by western blot analysis. The marker compounds of HRT-BU and fHRT-BU were analyzed by HPLC. The inhibitory effect of HRT or fHRT on ovariectomy-induced bone loss were evaluated using OVX rats with orally administered HRT, fHRT (300, 1000 mg/kg), or its vehicle for 12 weeks. fHRT-BU significantly inhibited RANKL-induced osteoclastogenesis, and phosphorylation of p38, IKKα/β, and NF-κBp65 compared to HRT-BU. In addition, fHRT-BU also significantly inhibited the mRNA expression of Nfκb2, TNF-α, NFATc1, TRAP, ATPv0d2, and cathepsin K. Furthermore, administration of fHRT had a greater effect on the increase of BMD, and greater improved bone microstructure of the femora than that of HRT in ovariectomy rats. This study demonstrated that bacterial fermentation enhances the inhibitory effect of HRT on osteoclastogenesis and bone loss. These results suggest that fermented HRT might have the beneficial effects on bone disease by inhibiting osteoclastogenesis. |
| doi_str_mv | 10.1155/2012/325791 |
| format | Article |
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We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages. mRNA expression of osteoclastogenesis-related genes were evaluated by real-time QPCR. The activation of signaling pathways was determined by western blot analysis. The marker compounds of HRT-BU and fHRT-BU were analyzed by HPLC. The inhibitory effect of HRT or fHRT on ovariectomy-induced bone loss were evaluated using OVX rats with orally administered HRT, fHRT (300, 1000 mg/kg), or its vehicle for 12 weeks. fHRT-BU significantly inhibited RANKL-induced osteoclastogenesis, and phosphorylation of p38, IKKα/β, and NF-κBp65 compared to HRT-BU. In addition, fHRT-BU also significantly inhibited the mRNA expression of Nfκb2, TNF-α, NFATc1, TRAP, ATPv0d2, and cathepsin K. Furthermore, administration of fHRT had a greater effect on the increase of BMD, and greater improved bone microstructure of the femora than that of HRT in ovariectomy rats. This study demonstrated that bacterial fermentation enhances the inhibitory effect of HRT on osteoclastogenesis and bone loss. These results suggest that fermented HRT might have the beneficial effects on bone disease by inhibiting osteoclastogenesis.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2012/325791</identifier><identifier>PMID: 23082080</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Bone loss ; Bone marrow ; Bone mineral density ; Butanol ; Cathepsin K ; Fermentation ; Gene expression ; Herbal medicine ; High-performance liquid chromatography ; Kinases ; Lactobacilli ; Lactobacillus casei ; Liquid chromatography ; Macrophages ; Medicine ; NF-κB protein ; Nutrition research ; Oral administration ; Osteoclastogenesis ; Osteoporosis ; Ovariectomy ; Phosphorylation ; Proteins ; Rats ; Rodents ; Signal transduction ; TRANCE protein ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-12</ispartof><rights>Copyright © 2012 Ki-Shuk Shim et al.</rights><rights>Copyright © 2012 Ki-Shuk Shim et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2012 Ki-Shuk Shim et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-67352d0f46f4a890466dd61cf8690399fab7be36183c49357b0f7bb174367a093</citedby><cites>FETCH-LOGICAL-c463t-67352d0f46f4a890466dd61cf8690399fab7be36183c49357b0f7bb174367a093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468024/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468024/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23082080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mo, HuanBiao</contributor><contributor>HuanBiao Mo</contributor><creatorcontrib>Ma, Jin Yeul</creatorcontrib><creatorcontrib>Kim, Han Sung</creatorcontrib><creatorcontrib>Cho, Chang-Won</creatorcontrib><creatorcontrib>Ha, Hyunil</creatorcontrib><creatorcontrib>Kim, Taesoo</creatorcontrib><creatorcontrib>Shim, Ki-Shuk</creatorcontrib><creatorcontrib>Seo, Dong-Hyun</creatorcontrib><title>Hwangryun-Haedok-Tang Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Hwangryun-haedok-tang (HRT) is the common recipe in traditional Asian medicine, and microbial fermentation is used for the conventional methods for processing traditional medicine. We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages. mRNA expression of osteoclastogenesis-related genes were evaluated by real-time QPCR. The activation of signaling pathways was determined by western blot analysis. The marker compounds of HRT-BU and fHRT-BU were analyzed by HPLC. The inhibitory effect of HRT or fHRT on ovariectomy-induced bone loss were evaluated using OVX rats with orally administered HRT, fHRT (300, 1000 mg/kg), or its vehicle for 12 weeks. fHRT-BU significantly inhibited RANKL-induced osteoclastogenesis, and phosphorylation of p38, IKKα/β, and NF-κBp65 compared to HRT-BU. In addition, fHRT-BU also significantly inhibited the mRNA expression of Nfκb2, TNF-α, NFATc1, TRAP, ATPv0d2, and cathepsin K. Furthermore, administration of fHRT had a greater effect on the increase of BMD, and greater improved bone microstructure of the femora than that of HRT in ovariectomy rats. This study demonstrated that bacterial fermentation enhances the inhibitory effect of HRT on osteoclastogenesis and bone loss. These results suggest that fermented HRT might have the beneficial effects on bone disease by inhibiting osteoclastogenesis.</description><subject>Acids</subject><subject>Bone loss</subject><subject>Bone marrow</subject><subject>Bone mineral density</subject><subject>Butanol</subject><subject>Cathepsin K</subject><subject>Fermentation</subject><subject>Gene expression</subject><subject>Herbal medicine</subject><subject>High-performance liquid chromatography</subject><subject>Kinases</subject><subject>Lactobacilli</subject><subject>Lactobacillus casei</subject><subject>Liquid chromatography</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>NF-κB protein</subject><subject>Nutrition research</subject><subject>Oral administration</subject><subject>Osteoclastogenesis</subject><subject>Osteoporosis</subject><subject>Ovariectomy</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>TRANCE protein</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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Chang-Won</creator><creator>Ha, Hyunil</creator><creator>Kim, Taesoo</creator><creator>Shim, Ki-Shuk</creator><creator>Seo, Dong-Hyun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi 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Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss</title><author>Ma, Jin Yeul ; Kim, Han Sung ; Cho, Chang-Won ; Ha, Hyunil ; Kim, Taesoo ; Shim, Ki-Shuk ; Seo, Dong-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-67352d0f46f4a890466dd61cf8690399fab7be36183c49357b0f7bb174367a093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acids</topic><topic>Bone loss</topic><topic>Bone marrow</topic><topic>Bone mineral density</topic><topic>Butanol</topic><topic>Cathepsin K</topic><topic>Fermentation</topic><topic>Gene expression</topic><topic>Herbal medicine</topic><topic>High-performance liquid chromatography</topic><topic>Kinases</topic><topic>Lactobacilli</topic><topic>Lactobacillus casei</topic><topic>Liquid chromatography</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>NF-κB protein</topic><topic>Nutrition research</topic><topic>Oral administration</topic><topic>Osteoclastogenesis</topic><topic>Osteoporosis</topic><topic>Ovariectomy</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>TRANCE protein</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jin Yeul</creatorcontrib><creatorcontrib>Kim, Han Sung</creatorcontrib><creatorcontrib>Cho, Chang-Won</creatorcontrib><creatorcontrib>Ha, Hyunil</creatorcontrib><creatorcontrib>Kim, Taesoo</creatorcontrib><creatorcontrib>Shim, Ki-Shuk</creatorcontrib><creatorcontrib>Seo, Dong-Hyun</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing 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Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hwangryun-Haedok-Tang Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Hwangryun-haedok-tang (HRT) is the common recipe in traditional Asian medicine, and microbial fermentation is used for the conventional methods for processing traditional medicine. We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages. mRNA expression of osteoclastogenesis-related genes were evaluated by real-time QPCR. The activation of signaling pathways was determined by western blot analysis. The marker compounds of HRT-BU and fHRT-BU were analyzed by HPLC. The inhibitory effect of HRT or fHRT on ovariectomy-induced bone loss were evaluated using OVX rats with orally administered HRT, fHRT (300, 1000 mg/kg), or its vehicle for 12 weeks. fHRT-BU significantly inhibited RANKL-induced osteoclastogenesis, and phosphorylation of p38, IKKα/β, and NF-κBp65 compared to HRT-BU. In addition, fHRT-BU also significantly inhibited the mRNA expression of Nfκb2, TNF-α, NFATc1, TRAP, ATPv0d2, and cathepsin K. Furthermore, administration of fHRT had a greater effect on the increase of BMD, and greater improved bone microstructure of the femora than that of HRT in ovariectomy rats. This study demonstrated that bacterial fermentation enhances the inhibitory effect of HRT on osteoclastogenesis and bone loss. These results suggest that fermented HRT might have the beneficial effects on bone disease by inhibiting osteoclastogenesis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23082080</pmid><doi>10.1155/2012/325791</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Acids Bone loss Bone marrow Bone mineral density Butanol Cathepsin K Fermentation Gene expression Herbal medicine High-performance liquid chromatography Kinases Lactobacilli Lactobacillus casei Liquid chromatography Macrophages Medicine NF-κB protein Nutrition research Oral administration Osteoclastogenesis Osteoporosis Ovariectomy Phosphorylation Proteins Rats Rodents Signal transduction TRANCE protein Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Hwangryun-Haedok-Tang Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss |
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