Do autologous growth factors enhance transforaminal lumbar interbody fusion?
Pseudarthrosis remains a significant problem in spinal fusion. The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF wit...
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| Veröffentlicht in: | European spine journal 2003-08, Vol.12 (4), p.400-407 |
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| creator | Hee, Hwan T Majd, Mohammad E Holt, Richard T Myers, Leann |
| description | Pseudarthrosis remains a significant problem in spinal fusion. The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF with application of AGF, with a minimum 2-year follow-up. Comparison with our historical cohort (without AGF application) was performed. Mean age at surgery was 44.3 years in the AGF treatment group. Twelve had a positive smoking history. Fourteen had undergone previous spinal surgeries. Thirteen received one-level fusions and ten received two-level fusions. The radiographic results showed a fusion rate of 100% in one-level fusions and 90% in two-level fusions. There was no significant difference in pseudarthrosis rates between the AGF treatment group and historical cohort. Excluding the cases with pseudarthrosis, there was faster bony healing in patients who had been treated with AGF application. This study indicates that although AGF may demonstrate faster fusions, it does not result in an overall increase in spinal fusion rates. Further studies are needed before AGF can routinely be used as an adjunct in spinal fusion. |
| doi_str_mv | 10.1007/s00586-003-0548-5 |
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The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF with application of AGF, with a minimum 2-year follow-up. Comparison with our historical cohort (without AGF application) was performed. Mean age at surgery was 44.3 years in the AGF treatment group. Twelve had a positive smoking history. Fourteen had undergone previous spinal surgeries. Thirteen received one-level fusions and ten received two-level fusions. The radiographic results showed a fusion rate of 100% in one-level fusions and 90% in two-level fusions. There was no significant difference in pseudarthrosis rates between the AGF treatment group and historical cohort. Excluding the cases with pseudarthrosis, there was faster bony healing in patients who had been treated with AGF application. This study indicates that although AGF may demonstrate faster fusions, it does not result in an overall increase in spinal fusion rates. Further studies are needed before AGF can routinely be used as an adjunct in spinal fusion.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-003-0548-5</identifier><identifier>PMID: 12761669</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Bone Transplantation ; Cohort Studies ; Female ; Follow-Up Studies ; Growth Substances - therapeutic use ; Humans ; Intervertebral Disc - diagnostic imaging ; Intervertebral Disc - surgery ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - surgery ; Male ; Original ; Platelet-Derived Growth Factor - therapeutic use ; Prospective Studies ; Pseudarthrosis - prevention & control ; Radiography ; Spinal Diseases - diagnostic imaging ; Spinal Diseases - surgery ; Spinal Fusion ; Time Factors ; Transforming Growth Factor beta - therapeutic use ; Wound Healing</subject><ispartof>European spine journal, 2003-08, Vol.12 (4), p.400-407</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-b0d98fd671d56a68c8bcb6d34031aac5e86d7e097f3973ca22f2dd0474b3a1e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467795/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467795/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12761669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hee, Hwan T</creatorcontrib><creatorcontrib>Majd, Mohammad E</creatorcontrib><creatorcontrib>Holt, Richard T</creatorcontrib><creatorcontrib>Myers, Leann</creatorcontrib><title>Do autologous growth factors enhance transforaminal lumbar interbody fusion?</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><description>Pseudarthrosis remains a significant problem in spinal fusion. The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF with application of AGF, with a minimum 2-year follow-up. Comparison with our historical cohort (without AGF application) was performed. Mean age at surgery was 44.3 years in the AGF treatment group. Twelve had a positive smoking history. Fourteen had undergone previous spinal surgeries. Thirteen received one-level fusions and ten received two-level fusions. The radiographic results showed a fusion rate of 100% in one-level fusions and 90% in two-level fusions. There was no significant difference in pseudarthrosis rates between the AGF treatment group and historical cohort. Excluding the cases with pseudarthrosis, there was faster bony healing in patients who had been treated with AGF application. This study indicates that although AGF may demonstrate faster fusions, it does not result in an overall increase in spinal fusion rates. Further studies are needed before AGF can routinely be used as an adjunct in spinal fusion.</description><subject>Adult</subject><subject>Bone Transplantation</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Growth Substances - therapeutic use</subject><subject>Humans</subject><subject>Intervertebral Disc - diagnostic imaging</subject><subject>Intervertebral Disc - surgery</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Original</subject><subject>Platelet-Derived Growth Factor - therapeutic use</subject><subject>Prospective Studies</subject><subject>Pseudarthrosis - prevention & control</subject><subject>Radiography</subject><subject>Spinal Diseases - diagnostic imaging</subject><subject>Spinal Diseases - surgery</subject><subject>Spinal Fusion</subject><subject>Time Factors</subject><subject>Transforming Growth Factor beta - therapeutic use</subject><subject>Wound Healing</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkc1u2zAQhImiRe06eYBcAqGH3tQuRYo_lwSB26QFDOSSnAmKpGwZEumQUgO_fWjYSNKe9rCzg9n5ELrA8B0D8B8JoBasBCAl1FSU9Qc0x5RUJUhSfURzkBRKxrGcoS8pbQFwLYF9RjNccYYZk3O0-hkKPY2hD-swpWIdw_O4KVptxhBT4fxGe-OKMWqf2hD10HndF_00NDoWnR9dbILdF-2UuuCvz9CnVvfJnZ_mAj3e_npY_i5X93d_ljer0lAhxrIBK0VrczBbM82EEY1pmCUUCNba1E4wyx1I3hLJidFV1VbWAuW0IRo7TBbo6ui7m5rBWeN8DtirXewGHfcq6E79u_HdRq3DX0Uo41zW2eDbySCGp8mlUQ1dMq7vtXe5BsUJw0RikYVf_xNuwxRzB0lVBLIbozKL8FFkYkgpuvY1CQZ1AKWOoFQGpQ6g1CHB5fsX3i5OZMgLdrmQfQ</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Hee, Hwan T</creator><creator>Majd, Mohammad E</creator><creator>Holt, Richard T</creator><creator>Myers, Leann</creator><general>Springer Nature B.V</general><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030801</creationdate><title>Do autologous growth factors enhance transforaminal lumbar interbody fusion?</title><author>Hee, Hwan T ; Majd, Mohammad E ; Holt, Richard T ; Myers, Leann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-b0d98fd671d56a68c8bcb6d34031aac5e86d7e097f3973ca22f2dd0474b3a1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Bone Transplantation</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Growth Substances - therapeutic use</topic><topic>Humans</topic><topic>Intervertebral Disc - diagnostic imaging</topic><topic>Intervertebral Disc - surgery</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Original</topic><topic>Platelet-Derived Growth Factor - therapeutic use</topic><topic>Prospective Studies</topic><topic>Pseudarthrosis - prevention & control</topic><topic>Radiography</topic><topic>Spinal Diseases - diagnostic imaging</topic><topic>Spinal Diseases - surgery</topic><topic>Spinal Fusion</topic><topic>Time Factors</topic><topic>Transforming Growth Factor beta - therapeutic use</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hee, Hwan T</creatorcontrib><creatorcontrib>Majd, Mohammad E</creatorcontrib><creatorcontrib>Holt, Richard T</creatorcontrib><creatorcontrib>Myers, Leann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hee, Hwan T</au><au>Majd, Mohammad E</au><au>Holt, Richard T</au><au>Myers, Leann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do autologous growth factors enhance transforaminal lumbar interbody fusion?</atitle><jtitle>European spine journal</jtitle><addtitle>Eur Spine J</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>12</volume><issue>4</issue><spage>400</spage><epage>407</epage><pages>400-407</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Pseudarthrosis remains a significant problem in spinal fusion. The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF with application of AGF, with a minimum 2-year follow-up. Comparison with our historical cohort (without AGF application) was performed. Mean age at surgery was 44.3 years in the AGF treatment group. Twelve had a positive smoking history. Fourteen had undergone previous spinal surgeries. Thirteen received one-level fusions and ten received two-level fusions. The radiographic results showed a fusion rate of 100% in one-level fusions and 90% in two-level fusions. There was no significant difference in pseudarthrosis rates between the AGF treatment group and historical cohort. Excluding the cases with pseudarthrosis, there was faster bony healing in patients who had been treated with AGF application. 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| subjects | Adult Bone Transplantation Cohort Studies Female Follow-Up Studies Growth Substances - therapeutic use Humans Intervertebral Disc - diagnostic imaging Intervertebral Disc - surgery Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - surgery Male Original Platelet-Derived Growth Factor - therapeutic use Prospective Studies Pseudarthrosis - prevention & control Radiography Spinal Diseases - diagnostic imaging Spinal Diseases - surgery Spinal Fusion Time Factors Transforming Growth Factor beta - therapeutic use Wound Healing |
| title | Do autologous growth factors enhance transforaminal lumbar interbody fusion? |
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