BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics
BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear. We evaluated the asso...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2012-10, Vol.21 (10), p.1792-1798 |
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| creator | PHIPPS, Amanda I BUCHANAN, Daniel D NEWCOMB, Polly A MAKAR, Karen W BURNETT-HARTMAN, Andrea N COGHILL, Anna E PASSARELLI, Michael N BARON, John A AHNEN, Dennis J AUNG KO WIN POTTER, John D |
| description | BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific and overall survival. Stratified analyses were conducted by age, sex, tumor site, stage, and MSI status.
Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed at ages A (p.V600E) mutation is associated with significantly poorer prognosis after CRC diagnosis among subgroups of patients. |
| doi_str_mv | 10.1158/1055-9965.epi-12-0674 |
| format | Article |
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific and overall survival. Stratified analyses were conducted by age, sex, tumor site, stage, and MSI status.
Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed at ages <50 (HR, 3.06; 95% CI, 1.70-5.52) and was not evident in cases with MSI-high tumors (HR, 0.94; 95% CI, 0.44-2.03). Associations with overall survival were similar.
Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
The presence of a BRAF c.1799T>A (p.V600E) mutation is associated with significantly poorer prognosis after CRC diagnosis among subgroups of patients.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.epi-12-0674</identifier><identifier>PMID: 22899730</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Microsatellite Instability ; Middle Aged ; Mutation ; Prospective Studies ; Proto-Oncogene Proteins B-raf - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2012-10, Vol.21 (10), p.1792-1798</ispartof><rights>2015 INIST-CNRS</rights><rights>2012 AACR</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-bbca86bccbad4b2fb37b30192b7caa86272fd96977151bd1402e19aadb9f7f753</citedby><cites>FETCH-LOGICAL-c507t-bbca86bccbad4b2fb37b30192b7caa86272fd96977151bd1402e19aadb9f7f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26424812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22899730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PHIPPS, Amanda I</creatorcontrib><creatorcontrib>BUCHANAN, Daniel D</creatorcontrib><creatorcontrib>NEWCOMB, Polly A</creatorcontrib><creatorcontrib>MAKAR, Karen W</creatorcontrib><creatorcontrib>BURNETT-HARTMAN, Andrea N</creatorcontrib><creatorcontrib>COGHILL, Anna E</creatorcontrib><creatorcontrib>PASSARELLI, Michael N</creatorcontrib><creatorcontrib>BARON, John A</creatorcontrib><creatorcontrib>AHNEN, Dennis J</creatorcontrib><creatorcontrib>AUNG KO WIN</creatorcontrib><creatorcontrib>POTTER, John D</creatorcontrib><title>BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific and overall survival. Stratified analyses were conducted by age, sex, tumor site, stage, and MSI status.
Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed at ages <50 (HR, 3.06; 95% CI, 1.70-5.52) and was not evident in cases with MSI-high tumors (HR, 0.94; 95% CI, 0.44-2.03). Associations with overall survival were similar.
Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
The presence of a BRAF c.1799T>A (p.V600E) mutation is associated with significantly poorer prognosis after CRC diagnosis among subgroups of patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Prospective Studies</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9P3DAQxS1UVCj0I1D5UolLwH_iOL4gLVtokUCgQs_W2HEWV9l4sZ2V-u3rLQuF01gz7_1m5IfQESUnlIr2lBIhKqUaceJWvqKsIo2sd9A-FbytpBTiQ3m_aPbQp5R-E0KkEuIj2mOsVUpyso_i-c_ZJb6ZMmQfRnxf6pQwjB2-n-Lar2HA0GcX8TwMITqbS2MOoy2dbx4WY0g-4Zm1IXZ-XOAc8F0huTH_YzxMy1CsjxDBFohP2dt0iHZ7GJL7vK0H6NflxcP8R3V9-_1qPruurCAyV8ZYaBtjrYGuNqw3XBpOqGJGWigTJlnfqUZJSQU1Ha0Jc1QBdEb1speCH6CzZ-5qMkvX2XJUhEGvol9C_KMDeP1-MvpHvQhrzetGctYWwPEWEMPT5FLWS5-sGwYYXZiSpkSJhrO6ZkUqnqU2hpSi61_XUKI3eelNFnqThb64u9KU6U1exffl7Y2vrpeAiuDrVgDJwtDH8vc-_dc1Natbyvhfds2hqg</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>PHIPPS, Amanda I</creator><creator>BUCHANAN, Daniel D</creator><creator>NEWCOMB, Polly A</creator><creator>MAKAR, Karen W</creator><creator>BURNETT-HARTMAN, Andrea N</creator><creator>COGHILL, Anna E</creator><creator>PASSARELLI, Michael N</creator><creator>BARON, John A</creator><creator>AHNEN, Dennis J</creator><creator>AUNG KO WIN</creator><creator>POTTER, John D</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics</title><author>PHIPPS, Amanda I ; BUCHANAN, Daniel D ; NEWCOMB, Polly A ; MAKAR, Karen W ; BURNETT-HARTMAN, Andrea N ; COGHILL, Anna E ; PASSARELLI, Michael N ; BARON, John A ; AHNEN, Dennis J ; AUNG KO WIN ; POTTER, John D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-bbca86bccbad4b2fb37b30192b7caa86272fd96977151bd1402e19aadb9f7f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Prospective Studies</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PHIPPS, Amanda I</creatorcontrib><creatorcontrib>BUCHANAN, Daniel D</creatorcontrib><creatorcontrib>NEWCOMB, Polly A</creatorcontrib><creatorcontrib>MAKAR, Karen W</creatorcontrib><creatorcontrib>BURNETT-HARTMAN, Andrea N</creatorcontrib><creatorcontrib>COGHILL, Anna E</creatorcontrib><creatorcontrib>PASSARELLI, Michael N</creatorcontrib><creatorcontrib>BARON, John A</creatorcontrib><creatorcontrib>AHNEN, Dennis J</creatorcontrib><creatorcontrib>AUNG KO WIN</creatorcontrib><creatorcontrib>POTTER, John D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PHIPPS, Amanda I</au><au>BUCHANAN, Daniel D</au><au>NEWCOMB, Polly A</au><au>MAKAR, Karen W</au><au>BURNETT-HARTMAN, Andrea N</au><au>COGHILL, Anna E</au><au>PASSARELLI, Michael N</au><au>BARON, John A</au><au>AHNEN, Dennis J</au><au>AUNG KO WIN</au><au>POTTER, John D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>21</volume><issue>10</issue><spage>1792</spage><epage>1798</epage><pages>1792-1798</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific and overall survival. Stratified analyses were conducted by age, sex, tumor site, stage, and MSI status.
Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed at ages <50 (HR, 3.06; 95% CI, 1.70-5.52) and was not evident in cases with MSI-high tumors (HR, 0.94; 95% CI, 0.44-2.03). Associations with overall survival were similar.
Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
The presence of a BRAF c.1799T>A (p.V600E) mutation is associated with significantly poorer prognosis after CRC diagnosis among subgroups of patients.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>22899730</pmid><doi>10.1158/1055-9965.epi-12-0674</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Microsatellite Instability Middle Aged Mutation Prospective Studies Proto-Oncogene Proteins B-raf - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics |
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