A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment

Platelets play a supportive role in tumor metastasis. Impairment of platelet function within the tumor microenvironment may provide a clinically useful approach to inhibit metastasis. We developed a novel humanized single-chain antibody (scFv Ab) against integrin GPIIIa49-66 (named A11) capable of l...

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Veröffentlicht in:	Blood 2012-10, Vol.120 (14), p.2889-2898
Hauptverfasser:	Zhang, Wei, Dang, Suying, Hong, Tao, Tang, Jian, Fan, Jing, Bu, Dawei, Sun, Yanjie, Wang, Zhugang, Wisniewski, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - therapeutic use Biological and medical sciences Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - prevention & control Carcinoma, Lewis Lung - secondary Cell Adhesion Cell Movement Female Hematologic and hematopoietic diseases Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - immunology Humans Medical sciences Melanoma, Experimental - immunology Melanoma, Experimental - prevention & control Melanoma, Experimental - secondary Mice Mice, Inbred C57BL Neovascularization, Pathologic Peptide Fragments - immunology Platelet Activation - immunology Platelet Glycoprotein GPIIb-IIIa Complex - immunology Pneumology Single-Chain Antibodies - therapeutic use Thrombosis and Hemostasis Tumor Microenvironment - immunology Tumors of the respiratory system and mediastinum
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