Adaptive fuzzy control of nutrients concentration in fed-batch culture of mammalian cells

An adaptive fuzzy controller was developed to control the glucose and glutamine concentrations in the reactor constant at the desired level. The parameter values of the controller change during the cultivation according to the culture phase which was detected by the lactate concentration. Cultivatio...

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Veröffentlicht in:	Cytotechnology (Dordrecht) 1997-11, Vol.25 (1-3), p.9-15
Hauptverfasser:	Lenas, P, Kitade, T, Watanabe, H, Honda, H, Kobayashi, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Batch culture Cell culture Fed-batch culture Glucose Glutamine Mammalian cells
Online-Zugang:	Volltext
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