Time course of histomorphological changes in adipose tissue upon acute lipoatrophy

Abstract Background and aims Crown-like structures (CLS) are characteristic histopathology features of inflamed adipose tissues in obese mice and humans. In previous work, we suggested that these cells derived from macrophages primarily involved in the reabsorption of dead adipocytes. Here, we used...

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Veröffentlicht in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2013-08, Vol.23 (8), p.723-731
Hauptverfasser:	Murano, I, Rutkowski, J.M, Wang, Q.A, Cho, Y.-R, Scherer, P.E, Cinti, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adipocytes Adipocytes - cytology Adipocytes - pathology Adiponectin Adiponectin - blood adipose tissue Adipose Tissue - pathology adults animal models Animals Apoptosis blood Cardiovascular Carrier Proteins Carrier Proteins - metabolism Caspase 8 Caspase 8 - metabolism CLS cytology death dimerization electron microscopy Fat FAT ATTAC genetically modified organisms histopathology humans immunohistochemistry Inflammation Inflammation - pathology lipids Lipodystrophy Lipodystrophy - pathology lymphocytes macrophages Macrophages - cytology Male metabolism Mice Mice, Obese Mice, Transgenic Microscopy, Electron mitochondria Mitochondria - pathology neutrophils Neutrophils - cytology pathology Perilipin-1 Phosphoproteins Phosphoproteins - metabolism
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