Interleukin-33 Is hepatoprotective during liver ischemia/reperfusion in mice

Interleukin (IL)‐33 is a recently identified member of the IL‐1 family that binds to the receptor, ST2L. In the current study, we sought to determine whether IL‐33 is an important regulator in the hepatic response to ischemia/reperfusion (I/R). Male C57BL/6 mice were subjected to 90 minutes of parti...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-10, Vol.56 (4), p.1468-1478
Hauptverfasser:	Sakai, Nozomu, Van Sweringen, Heather L., Quillin, R. Cutler, Schuster, Rebecca, Blanchard, John, Burns, Justin M., Tevar, Amit D., Edwards, Michael J., Lentsch, Alex B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Blotting, Western Cardiology. Vascular system Cells, Cultured Cyclin D1 - genetics Cyclin D1 - metabolism Cytokines Cytokines - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Gastroenterology. Liver. Pancreas. Abdomen Hepatocytes - metabolism Hepatology Interleukin-33 Interleukins - metabolism Interleukins - pharmacology Ischemia Kinases Kupffer Cells - metabolism Liver Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Inbred C57BL NF-kappa B - metabolism Other diseases. Semiology Oxidative Stress p38 Mitogen-Activated Protein Kinases - metabolism Protein expression Proteins Random Allocation Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Reperfusion Injury - therapy Rodents
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