MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome

Background: Neuroblastoma remains a major cause of cancer-linked mortality in children. miR-204 has been used in microRNA expression signatures predictive of neuroblastoma patient survival. The aim of this study was to explore the independent association of miR-204 with survival in a neuroblastoma c...

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Veröffentlicht in:	British journal of cancer 2012-09, Vol.107 (6), p.967-976
Hauptverfasser:	Ryan, J, Tivnan, A, Fay, J, Bryan, K, Meehan, M, Creevey, L, Lynch, J, Bray, I M, O'Meara, A, Davidoff, A M, Stallings, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2326 631/67/1059/99 692/53/2423 692/699/67/1922 Analysis of Variance Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Cell Survival - genetics Cisplatin - pharmacology Clinical outcomes Disease Models, Animal Disease-Free Survival Down-Regulation - drug effects Drug Resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epidemiology Etoposide - pharmacology Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Medical sciences Membrane Glycoproteins - drug effects Membrane Glycoproteins - metabolism Mice Mice, Inbred Strains Mice, SCID MicroRNAs - pharmacology Molecular Medicine Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - mortality Neurology Oncology Predictive Value of Tests Proportional Hazards Models Protein-Tyrosine Kinases - drug effects Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Real-Time Polymerase Chain Reaction Receptor, trkB - drug effects Receptor, trkB - metabolism Reverse Transcriptase Polymerase Chain Reaction Translational Therapeutics Tumors Tumors of the nervous system. Phacomatoses Up-Regulation
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