Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

Viral double-stranded RNA, a ligand for Toll-like Receptor 3 (TLR3) and the cytoplasmic RNA receptors RIG1 and MDA5, activate a signaling network in which the IKK-related protein kinase TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquitin ligase Pel...

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Veröffentlicht in:	The Journal of biological chemistry 2012-10, Vol.287 (41), p.34825-34835
Hauptverfasser:	Enesa, Karine, Ordureau, Alban, Smith, Hilary, Barford, David, Cheung, Peter C.F., Patterson-Kane, Janet, Arthur, J.Simon C., Cohen, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Cell Nucleus - genetics Cell Nucleus - metabolism DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism E3 Ubiquitin Ligase Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gene Knock-In Techniques Immunology Interferon Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Interferon-beta - biosynthesis Interferon-beta - genetics Interferon-Induced Helicase, IFIH1 IRF3 Macrophages Mice Mice, Transgenic Nuclear Proteins - genetics Nuclear Proteins - metabolism Pellino Promoter Regions, Genetic - physiology Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Viral - genetics RNA, Viral - metabolism Signal Transduction - physiology TBK1 Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Toll-like Receptors (TLR) Transcription, Genetic - physiology Ubiquitin-Protein Ligases Viral RNA Virus
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