Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing my...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2012-06, Vol.125 (23), p.2844-2853
Hauptverfasser:	CHOKSHI, Aalap, DROSATOS, Konstantinos, MILTING, Hendrik, CHUNG, Christine S, JORDE, Ulrich, NAKA, Yoshifumi, MANCINI, Donna M, GOLDBERG, Ira J, CHRISTIAN SCHULZE, P, CHEEMA, Faisal H, RUIPING JI, KHAWAJA, Tuba, SHUIQING YU, KATO, Tomoko, KHAN, Raffay, TAKAYAMA, Hiroo, KNOLL, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cell Line Ceramides - metabolism Diglycerides - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fatty Acids - metabolism Female Heart Failure - diagnostic imaging Heart Failure - metabolism Heart Failure - surgery Heart-Assist Devices Humans Insulin - metabolism Insulin Resistance - physiology Lipid Metabolism - physiology Male Medical sciences Middle Aged Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Pharmacology. Drug treatments Protein Kinase C - metabolism Retrospective Studies Severity of Illness Index Signal Transduction - physiology Triglycerides - metabolism Ultrasonography Vasodilator agents. Cerebral vasodilators
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