Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys

Within the group I family of metabotropic glutamate receptors (mGluRs), substantial evidence points to a role for mGluR5 mechanisms in cocaine's abuse-related behavioral effects, but less is understood about the contribution of mGluR1, which also belongs to the group I mGluR family. The selecti...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-10, Vol.343 (1), p.214-224
Hauptverfasser:	Achat-Mendes, Cindy, Platt, Donna M, Spealman, Roger D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Addictive - prevention & control Behavior, Addictive - psychology Behavioral Pharmacology Cocaine - administration & dosage Dose-Response Relationship, Drug Male Methamphetamine - administration & dosage Quinolines - pharmacology Quinolines - therapeutic use Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Saimiri Self Administration Treatment Outcome
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