Study of Highly Constitutively Active Mutants Suggests How cAMP Activates cAMP Receptor Protein

The cAMP receptor protein (CRP) of Escherichia coli undergoes a conformational change in response to cAMP binding that allows it to bind specific DNA sequences. Using an in vivo screening method following the simultaneous randomization of the codons at positions 127 and 128 (two C-helix residues of...

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Veröffentlicht in:	The Journal of biological chemistry 2006-01, Vol.281 (2), p.1119-1127
Hauptverfasser:	Youn, Hwan, Kerby, Robert L., Conrad, Mary, Roberts, Gary P.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Galactosidase - metabolism C-Reactive Protein - chemistry Cyclic AMP - metabolism Cyclic AMP Receptor Protein - metabolism Dimerization DNA - chemistry Escherichia coli Escherichia coli - metabolism Leucine - chemistry Methionine - chemistry Models, Molecular Mutation Plasmids - metabolism Promoter Regions, Genetic Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Receptors, Cyclic AMP - chemistry Serine - chemistry Threonine - chemistry Time Factors Transcription, Genetic
Online-Zugang:	Volltext
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