Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma

In this study, we assessed the specific role of BRAF(V600E) signaling in modulating the expression of immune regulatory genes in melanoma, in addition to analyzing downstream induction of immune suppression by primary human melanoma tumor-associated fibroblasts (TAF). Primary human melanocytes and m...

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Veröffentlicht in:	Clinical cancer research 2012-10, Vol.18 (19), p.5329-5340
Hauptverfasser:	KHALILI, Jahan S, SHUJUAN LIU, MIN ZHANG, JOSEPH, Richard W, BERNATCHEZ, Chantale, EKMEKCIOGLU, Suhendan, GRIMM, Elizabeth, RADVANYI, Laszlo G, DAVIS, Richard E, DAVIES, Michael A, WARGO, Jennifer A, HWU, Patrick, RODRIGUEZ-CRUZ, Tania G, LIZEE, Gregory, WHITTINGTON, Mayra, WARDELL, Seth, CHENGWEN LIU, MINYING ZHANG, COOPER, Zachary A, FREDERICK, Dennie T, YUFENG LI
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Dermatology Gene Expression Regulation, Neoplastic - drug effects Humans Immunosuppression Indoles - administration & dosage Interleukin-1alpha - genetics Interleukin-1alpha - immunology Interleukin-1alpha - metabolism Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-1beta - metabolism Medical sciences Melanocytes - cytology Melanocytes - drug effects Melanoma - drug therapy Melanoma - immunology Melanoma - pathology Pharmacology. Drug treatments Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - immunology Stromal Cells - cytology Stromal Cells - drug effects Sulfonamides - administration & dosage T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Microenvironment - immunology Tumors of the skin and soft tissue. Premalignant lesions
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