Cortical silent period duration and its implications for surround inhibition of a hand muscle
Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribu...
Gespeichert in:
| Veröffentlicht in: | The European journal of neuroscience 2012-10, Vol.36 (7), p.2964-2971 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2971 |
|---|---|
| container_issue | 7 |
| container_start_page | 2964 |
| container_title | The European journal of neuroscience |
| container_volume | 36 |
| creator | Poston, Brach Kukke, Sahana N. Paine, Rainer W. Francis, Sophia Hallett, Mark |
| description | Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as assessed by the cortical silent period (CSP), to the generation of surround inhibition in the motor system. Eight healthy adults (five women and three men, 29.8 ± 9 years) performed isometric contractions with the abductor digiti minimi (ADM) muscle in separate conditions with and without an index finger flexion movement. The ADM motor evoked potential amplitude and CSP duration elicited by transcranial magnetic stimulation were compared between a control condition in which the ADM was activated independently and during conditions involving three phases (pre‐motor, phasic, and tonic) of the index finger flexion movement. The motor evoked potential amplitude of the ADM was greater during the control condition compared with the phasic condition. Thus, the presence of surround inhibition was confirmed in the present study. Most critically, the CSP duration of the ADM decreased during the phasic stage of finger flexion compared with the control condition, which indicated a reduction of this type of intracortical inhibition during the phasic condition. These findings indicate that γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as measured by the duration of the CSP, does not contribute to the generation of surround inhibition in hand muscles.
Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of GABAB receptor mediated intracortical inhibition as assessed by the cortical silent period (CSP) to the generation of surround inhibition in the motor system. |
| doi_str_mv | 10.1111/j.1460-9568.2012.08212.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3463678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1082237187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5452-d32c6cad5debb3c26ebb9e074e8724f734b61c87867cc7980707018ae4587eb63</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS0EokPhLyAv2WTwI35kARIdlVJUygYoG3TlOA7jIYmndgLTf1-nU0awAlvytXy_c2T7IIQpWdI8Xm6WtJSkqITUS0YoWxLN8rp7gBaHxkO0IJXghaby6xF6ktKGEKJlKR6jI8aUEpywBfq2CnH01nQ4-c4NI9666EODmyma0YcBm6HBfkzY99suc_NZwm2IOE0xhmnuDmtf-zs4tNjg9Szpp2Q79xQ9ak2X3LP7eow-vz39tHpXXHw8O1-9uSisKAUrGs6stKYRjatrbpnMpXJElU4rVraKl7WkVistlbWq0kTlSbVxpdDK1ZIfo9d73-1U966x-SHRdLCNvjfxBoLx8Hdn8Gv4Hn4CLyWXSmeDF_cGMVxPLo3Q-2Rd15nBhSlB_nTOGOe6_Deas2BcUa0yqveojSGl6NrDjSiZLSlsYM4L5rxgDhLugoRdlj7_80UH4e_kMvBqD_zKud38tzGcvr-cd1lf7PU-jW530Jv4A6TiSsDV5Rl8-FIxenKl4ITfAoiVvQk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1082237187</pqid></control><display><type>article</type><title>Cortical silent period duration and its implications for surround inhibition of a hand muscle</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Poston, Brach ; Kukke, Sahana N. ; Paine, Rainer W. ; Francis, Sophia ; Hallett, Mark</creator><creatorcontrib>Poston, Brach ; Kukke, Sahana N. ; Paine, Rainer W. ; Francis, Sophia ; Hallett, Mark</creatorcontrib><description>Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as assessed by the cortical silent period (CSP), to the generation of surround inhibition in the motor system. Eight healthy adults (five women and three men, 29.8 ± 9 years) performed isometric contractions with the abductor digiti minimi (ADM) muscle in separate conditions with and without an index finger flexion movement. The ADM motor evoked potential amplitude and CSP duration elicited by transcranial magnetic stimulation were compared between a control condition in which the ADM was activated independently and during conditions involving three phases (pre‐motor, phasic, and tonic) of the index finger flexion movement. The motor evoked potential amplitude of the ADM was greater during the control condition compared with the phasic condition. Thus, the presence of surround inhibition was confirmed in the present study. Most critically, the CSP duration of the ADM decreased during the phasic stage of finger flexion compared with the control condition, which indicated a reduction of this type of intracortical inhibition during the phasic condition. These findings indicate that γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as measured by the duration of the CSP, does not contribute to the generation of surround inhibition in hand muscles.
Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of GABAB receptor mediated intracortical inhibition as assessed by the cortical silent period (CSP) to the generation of surround inhibition in the motor system.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.2012.08212.x</identifier><identifier>PMID: 22775302</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Cortex ; Evoked Potentials, Motor - physiology ; facilitation ; Female ; Finger ; Fingers ; gamma -Aminobutyric acid B receptors ; Hand ; human ; Humans ; inhibition ; Isometric Contraction - physiology ; Male ; Motor Activity - physiology ; motor cortex ; Motor Cortex - physiology ; Motor evoked potentials ; Muscle contraction ; Muscle, Skeletal - physiology ; Muscles ; Nervous system ; Neural Inhibition ; Transcranial Magnetic Stimulation</subject><ispartof>The European journal of neuroscience, 2012-10, Vol.36 (7), p.2964-2971</ispartof><rights>Published 2012. This article is a US Government work and is in the public domain in the USA</rights><rights>Published 2012. This article is a US Government work and is in the public domain in the USA.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5452-d32c6cad5debb3c26ebb9e074e8724f734b61c87867cc7980707018ae4587eb63</citedby><cites>FETCH-LOGICAL-c5452-d32c6cad5debb3c26ebb9e074e8724f734b61c87867cc7980707018ae4587eb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9568.2012.08212.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9568.2012.08212.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22775302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poston, Brach</creatorcontrib><creatorcontrib>Kukke, Sahana N.</creatorcontrib><creatorcontrib>Paine, Rainer W.</creatorcontrib><creatorcontrib>Francis, Sophia</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><title>Cortical silent period duration and its implications for surround inhibition of a hand muscle</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as assessed by the cortical silent period (CSP), to the generation of surround inhibition in the motor system. Eight healthy adults (five women and three men, 29.8 ± 9 years) performed isometric contractions with the abductor digiti minimi (ADM) muscle in separate conditions with and without an index finger flexion movement. The ADM motor evoked potential amplitude and CSP duration elicited by transcranial magnetic stimulation were compared between a control condition in which the ADM was activated independently and during conditions involving three phases (pre‐motor, phasic, and tonic) of the index finger flexion movement. The motor evoked potential amplitude of the ADM was greater during the control condition compared with the phasic condition. Thus, the presence of surround inhibition was confirmed in the present study. Most critically, the CSP duration of the ADM decreased during the phasic stage of finger flexion compared with the control condition, which indicated a reduction of this type of intracortical inhibition during the phasic condition. These findings indicate that γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as measured by the duration of the CSP, does not contribute to the generation of surround inhibition in hand muscles.
Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of GABAB receptor mediated intracortical inhibition as assessed by the cortical silent period (CSP) to the generation of surround inhibition in the motor system.</description><subject>Adult</subject><subject>Cortex</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>facilitation</subject><subject>Female</subject><subject>Finger</subject><subject>Fingers</subject><subject>gamma -Aminobutyric acid B receptors</subject><subject>Hand</subject><subject>human</subject><subject>Humans</subject><subject>inhibition</subject><subject>Isometric Contraction - physiology</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>motor cortex</subject><subject>Motor Cortex - physiology</subject><subject>Motor evoked potentials</subject><subject>Muscle contraction</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscles</subject><subject>Nervous system</subject><subject>Neural Inhibition</subject><subject>Transcranial Magnetic Stimulation</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokPhLyAv2WTwI35kARIdlVJUygYoG3TlOA7jIYmndgLTf1-nU0awAlvytXy_c2T7IIQpWdI8Xm6WtJSkqITUS0YoWxLN8rp7gBaHxkO0IJXghaby6xF6ktKGEKJlKR6jI8aUEpywBfq2CnH01nQ4-c4NI9666EODmyma0YcBm6HBfkzY99suc_NZwm2IOE0xhmnuDmtf-zs4tNjg9Szpp2Q79xQ9ak2X3LP7eow-vz39tHpXXHw8O1-9uSisKAUrGs6stKYRjatrbpnMpXJElU4rVraKl7WkVistlbWq0kTlSbVxpdDK1ZIfo9d73-1U966x-SHRdLCNvjfxBoLx8Hdn8Gv4Hn4CLyWXSmeDF_cGMVxPLo3Q-2Rd15nBhSlB_nTOGOe6_Deas2BcUa0yqveojSGl6NrDjSiZLSlsYM4L5rxgDhLugoRdlj7_80UH4e_kMvBqD_zKud38tzGcvr-cd1lf7PU-jW530Jv4A6TiSsDV5Rl8-FIxenKl4ITfAoiVvQk</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Poston, Brach</creator><creator>Kukke, Sahana N.</creator><creator>Paine, Rainer W.</creator><creator>Francis, Sophia</creator><creator>Hallett, Mark</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201210</creationdate><title>Cortical silent period duration and its implications for surround inhibition of a hand muscle</title><author>Poston, Brach ; Kukke, Sahana N. ; Paine, Rainer W. ; Francis, Sophia ; Hallett, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5452-d32c6cad5debb3c26ebb9e074e8724f734b61c87867cc7980707018ae4587eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Cortex</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>facilitation</topic><topic>Female</topic><topic>Finger</topic><topic>Fingers</topic><topic>gamma -Aminobutyric acid B receptors</topic><topic>Hand</topic><topic>human</topic><topic>Humans</topic><topic>inhibition</topic><topic>Isometric Contraction - physiology</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>motor cortex</topic><topic>Motor Cortex - physiology</topic><topic>Motor evoked potentials</topic><topic>Muscle contraction</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscles</topic><topic>Nervous system</topic><topic>Neural Inhibition</topic><topic>Transcranial Magnetic Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poston, Brach</creatorcontrib><creatorcontrib>Kukke, Sahana N.</creatorcontrib><creatorcontrib>Paine, Rainer W.</creatorcontrib><creatorcontrib>Francis, Sophia</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poston, Brach</au><au>Kukke, Sahana N.</au><au>Paine, Rainer W.</au><au>Francis, Sophia</au><au>Hallett, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical silent period duration and its implications for surround inhibition of a hand muscle</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2012-10</date><risdate>2012</risdate><volume>36</volume><issue>7</issue><spage>2964</spage><epage>2971</epage><pages>2964-2971</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as assessed by the cortical silent period (CSP), to the generation of surround inhibition in the motor system. Eight healthy adults (five women and three men, 29.8 ± 9 years) performed isometric contractions with the abductor digiti minimi (ADM) muscle in separate conditions with and without an index finger flexion movement. The ADM motor evoked potential amplitude and CSP duration elicited by transcranial magnetic stimulation were compared between a control condition in which the ADM was activated independently and during conditions involving three phases (pre‐motor, phasic, and tonic) of the index finger flexion movement. The motor evoked potential amplitude of the ADM was greater during the control condition compared with the phasic condition. Thus, the presence of surround inhibition was confirmed in the present study. Most critically, the CSP duration of the ADM decreased during the phasic stage of finger flexion compared with the control condition, which indicated a reduction of this type of intracortical inhibition during the phasic condition. These findings indicate that γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as measured by the duration of the CSP, does not contribute to the generation of surround inhibition in hand muscles.
Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of GABAB receptor mediated intracortical inhibition as assessed by the cortical silent period (CSP) to the generation of surround inhibition in the motor system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22775302</pmid><doi>10.1111/j.1460-9568.2012.08212.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-816X |
| ispartof | The European journal of neuroscience, 2012-10, Vol.36 (7), p.2964-2971 |
| issn | 0953-816X 1460-9568 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3463678 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Cortex Evoked Potentials, Motor - physiology facilitation Female Finger Fingers gamma -Aminobutyric acid B receptors Hand human Humans inhibition Isometric Contraction - physiology Male Motor Activity - physiology motor cortex Motor Cortex - physiology Motor evoked potentials Muscle contraction Muscle, Skeletal - physiology Muscles Nervous system Neural Inhibition Transcranial Magnetic Stimulation |
| title | Cortical silent period duration and its implications for surround inhibition of a hand muscle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T07%3A42%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cortical%20silent%20period%20duration%20and%20its%20implications%20for%20surround%20inhibition%20of%20a%20hand%20muscle&rft.jtitle=The%20European%20journal%20of%20neuroscience&rft.au=Poston,%20Brach&rft.date=2012-10&rft.volume=36&rft.issue=7&rft.spage=2964&rft.epage=2971&rft.pages=2964-2971&rft.issn=0953-816X&rft.eissn=1460-9568&rft_id=info:doi/10.1111/j.1460-9568.2012.08212.x&rft_dat=%3Cproquest_pubme%3E1082237187%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1082237187&rft_id=info:pmid/22775302&rfr_iscdi=true |