The Receptor for Advanced Glycation End Products Is a Central Mediator of Asthma Pathogenesis

The receptor for advanced glycation end products (RAGE) is a multiligand receptor that has been shown to contribute to the pathogenesis of diabetes, atherosclerosis, and neurodegeneration. However, its role in asthma and allergic airway disease is largely unknown. These studies use a house dust mite...

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Veröffentlicht in:	The American journal of pathology 2012-10, Vol.181 (4), p.1215-1225
Hauptverfasser:	Milutinovic, Pavle S, Alcorn, John F, Englert, Judson M, Crum, Lauren T, Oury, Tim D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma - etiology Asthma - metabolism Asthma - pathology Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - parasitology Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Chemokine CCL24 Chronic obstructive pulmonary disease, asthma Eosinophilia - parasitology Eosinophilia - pathology Eosinophilia - physiopathology Immunoglobulin G - immunology Interleukin-13 - biosynthesis Interleukin-4 - biosynthesis Interleukin-4 - secretion Interleukin-5 - biosynthesis Investigative techniques, diagnostic techniques (general aspects) Lung - metabolism Lung - pathology Lung - physiopathology Male Medical sciences Mice Mice, Inbred C57BL Ovalbumin Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Protein Transport Pyroglyphidae - physiology Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Regular
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