TIPE2, a Novel Regulator of Immunity, Protects against Experimental Stroke

The inflammatory responses accompanying stroke are recognized to contribute to secondary ischemic injury. TIPE2 is a very recently identified negative regulator of inflammation that maintains immune homeostasis. However, it is unknown whether TIPE2 is expressed in the brain and contributes to the re...

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Veröffentlicht in:	The Journal of biological chemistry 2012-09, Vol.287 (39), p.32546-32555
Hauptverfasser:	Zhang, Yan, Wei, Xinbing, Liu, Lixia, Liu, Suxia, Wang, Ziying, Zhang, Bin, Fan, Baoxia, Yang, Fan, Huang, Shanying, Jiang, Fan, Chen, Youhai H., Yi, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebellum - immunology Cerebellum - metabolism Cerebellum - pathology Disease Models, Animal Immunology Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation - pathology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism Ischemia Macrophages - immunology Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Microglia - immunology Microglia - metabolism Microglia - pathology Molecular Bases of Disease NADPH Oxidase NADPH Oxidases - genetics NADPH Oxidases - immunology NADPH Oxidases - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Neuroimmunology Neutrophil Infiltration - genetics Neutrophil Infiltration - immunology Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Reactive Oxygen Species (ROS) Reperfusion Injury - genetics Reperfusion Injury - immunology Reperfusion Injury - metabolism Reperfusion Injury - pathology Signal Transduction Stroke Stroke - genetics Stroke - immunology Stroke - metabolism Stroke - pathology
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