Structure-toxicity relationship study of para-halogenated styrene analogues in CYP2E1 transgenic cells

► We investigated the structure-toxicity relationship of halogenated styrenes. ► Cytotoxicity order: 4-bromostyrene>4-chlorostyrene>4-fluorostyrene≈styrene. ► Bioactivation of the styrenes follows the same order of their toxicities. ► GSH depletion and protein covalent binding are consistent w...

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Veröffentlicht in:	Toxicology letters 2012-05, Vol.210 (3), p.353-359
Hauptverfasser:	Chung, Jou-Ku, Shen, Shuijie, Jiang, Zhiteng, Yuan, Wei, Zheng, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioactivation Biological and medical sciences Cell Line Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Cysteamine - metabolism Cytochrome P-450 CYP2E1 - physiology Glutathione - metabolism Humans Hydrocarbons, Halogenated - toxicity Medical sciences Protein adduct Protein Binding Solvents Structure-Activity Relationship Styrene Styrene oxide Styrenes - toxicity Toxicology
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