Estimating the Microtubule GTP Cap Size In Vivo

Microtubules (MTs) polymerize via net addition of GTP-tubulin subunits to the MT plus end, which subsequently hydrolyze to GDP-tubulin in the MT lattice. Relatively stable GTP-tubulin subunits create a “GTP cap” at the growing MT plus end that suppresses catastrophe. To understand MT assembly regula...

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Veröffentlicht in:	Current biology 2012-09, Vol.22 (18), p.1681-1687
Hauptverfasser:	Seetapun, Dominique, Castle, Brian T., McIntyre, Alistair J., Tran, Phong T., Odde, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	cortex epithelial cells Epithelial Cells - metabolism Guanosine Triphosphate - metabolism hydrolysis Microtubule-Associated Proteins - metabolism microtubules Microtubules - metabolism reaction kinetics tubulin Tubulin - metabolism
Online-Zugang:	Volltext
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