Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

Altered metabolism in tumor cells is increasingly recognized as a core component of the neoplastic phenotype. Because p53 has emerged as a master metabolic regulator, we hypothesized that the presence of wild-type p53 in glioblastoma cells could confer a selective advantage to these cells under the...

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Veröffentlicht in:	The Journal of biological chemistry 2012-09, Vol.287 (40), p.33436-33446
Hauptverfasser:	Wanka, Christina, Steinbach, Joachim P., Rieger, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins Brain Neoplasms - metabolism Cell Death Cell Line Cell Line, Tumor Cell Metabolism Gene Expression Regulation Gene Expression Regulation, Neoplastic Glioma Glioma - metabolism Glycolysis Humans Hypoxia Hypoxia - metabolism Intracellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - physiology Metabolism Mice Models, Biological Oxidation-Reduction Oxygen Consumption p53 Pentose Pathway Pentose Phosphate Pathway Phosphoric Monoester Hydrolases Reactive Oxygen Species TIGAR Tumor Suppressor Protein p53 - genetics
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