Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia

Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication-timing profiles for pediatric leukemias from 17 patients and three cell lines, as well as normal B and T cells. Nonleukemic EBV-transformed lymp...

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Veröffentlicht in:	Genome research 2012-10, Vol.22 (10), p.1833-1844
Hauptverfasser:	Ryba, Tyrone, Battaglia, Dana, Chang, Bill H, Shirley, James W, Buckley, Quinton, Pope, Benjamin D, Devidas, Meenakshi, Druker, Brian J, Gilbert, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormal Karyotype Cell Line Child DNA Copy Number Variations DNA Replication Timing Epigenesis, Genetic Gene Expression Profiling Genetic Heterogeneity Humans Leukemia - genetics Lymphocytes - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Translocation, Genetic
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