MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells

MicroRNAs have been implicated as important mediators of cancer cell homeostasis, and accumulating data suggest compelling roles for them in the apoptosis pathway. X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor and an important barrier to apoptotic cell death, but the m...

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Veröffentlicht in:	Oncogene 2013-05, Vol.32 (19), p.2442-2451
Hauptverfasser:	Xie, Y, Tobin, L A, Camps, J, Wangsa, D, Yang, J, Rao, M, Witasp, E, Awad, K S, Yoo, N, Ried, T, Kwong, K F
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 631/208/200 631/337/384/331 631/67 631/80/82/23 Analysis Apoptosis Apoptosis - genetics Apoptosis - physiology Bioinformatics Cancer Cancer cells Caspase Caspase inhibitors Cell Biology Cell death Cell Growth Processes - genetics Cell Growth Processes - physiology Cell Line, Tumor Copy number Down-Regulation Gene expression Genetic aspects Genomic analysis Health aspects HeLa Cells Homeostasis Human Genetics Humans Hybridization IAP protein Internal Medicine Karyotypes Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology original-article Proteins Ribonucleic acid RNA Site-directed mutagenesis TRAIL protein Transfection X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism XIAP protein
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