Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis

The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind to fibroblast growth factor (FGF) ligands and block the activation of the FGF-signaling pathway. In this study, sFGFR2c inhibited lung fibrosis dramatically in vitro and in vivo. The upregulation of α-smooth m...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2012-09, Vol.18 (6), p.992-1002
Hauptverfasser:	Ju, Wang, Zhihong, Yu, Zhiyou, Zhou, Qin, Huang, Dingding, Wang, Li, Sun, Baowei, Zhu, Xing, Wei, Ying, He, An, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - antagonists & inhibitors Actins - metabolism Animals Bleomycin Cell culture Cell Proliferation - drug effects Cells, Cultured Collagen Disease Models, Animal Enzyme Activation - drug effects Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation - drug effects Growth factors Humans Kinases Lungs Male MAP Kinase Signaling System - drug effects Medical research Mice Mice, Inbred C57BL Pneumonia - complications Pneumonia - genetics Pneumonia - pathology Protein Binding - drug effects Protein Isoforms - metabolism Protein Structure, Tertiary Proteins Pulmonary Fibrosis - enzymology Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology R&D Receptor, Fibroblast Growth Factor, Type 2 - chemistry Receptor, Fibroblast Growth Factor, Type 2 - metabolism Research & development Sensors Smad Proteins - metabolism Surface Plasmon Resonance Transforming Growth Factor beta1 - pharmacology
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