Prevalence and specificity of LKB1 genetic alterations in lung cancers

Germline LKB1 mutations cause Peutz–Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2007-08, Vol.26 (40), p.5911-5918
Hauptverfasser:	Matsumoto, S, Iwakawa, R, Takahashi, K, Kohno, T, Nakanishi, Y, Matsuno, Y, Suzuki, K, Nakamoto, M, Shimizu, E, Minna, J D, Yokota, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Aged Apoptosis Base Sequence Biological and medical sciences Carcinoma Carcinoma - genetics Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Contamination Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene mutations Genetic aspects Genetic disorders Genetics Health aspects Human Genetics Humans Internal Medicine LKB1 protein Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Male Medical sciences Medicine Medicine & Public Health Men Middle Aged Molecular and cellular biology Molecular Sequence Data Mutation Oncology original-article Physiological aspects Pneumology Polyposis Prevalence Protein-Serine-Threonine Kinases - genetics Risk factors Smoking Tobacco, tobacco smoking Toxicology Tumor cell lines Tumors Tumors of the respiratory system and mediastinum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!