Effects of aging on ovarian fecundity in terms of the incidence of apoptotic Granulosa cells
The objective was to determine the effects of women's age on the ovarian fecundity as assessed by the incidence of apoptotic granulosa cells. Twenty-eight normo-ovulatory women underwent ovulation induction for standard IVF. The husbands of these women showed severe male infertility factors. Th...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2000-03, Vol.17 (3), p.168-173 |
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| creator | SEYED HOMAYOON SADRAIE SAITO, H KANEKO, T SAITO, T HIROI, M |
| description | The objective was to determine the effects of women's age on the ovarian fecundity as assessed by the incidence of apoptotic granulosa cells.
Twenty-eight normo-ovulatory women underwent ovulation induction for standard IVF. The husbands of these women showed severe male infertility factors. The women were divided into four groups according to their ages. Women underwent follicle aspiration after the administration of human menopausal gonadotropin plus human chorionic gonadotropin. The nuclei of granulosa cells were examined by using fluorescence microscopy, and the incidence of apoptotic granulosa cells was tabulated.
Granulosa cells in the older women revealed a significant increase in the number of apoptotic cells. The number of total oocytes and the number of mature oocytes obtained significantly decreased with age. However, endometrial thickness and follicular estradiol, progesterone, and free testosterone levels were not significantly different among four different age groups.
Age increases apoptotic changes in granulosa cells and consequently decreases the ovarian fecundity. |
| doi_str_mv | 10.1023/A:1009422323306 |
| format | Article |
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Twenty-eight normo-ovulatory women underwent ovulation induction for standard IVF. The husbands of these women showed severe male infertility factors. The women were divided into four groups according to their ages. Women underwent follicle aspiration after the administration of human menopausal gonadotropin plus human chorionic gonadotropin. The nuclei of granulosa cells were examined by using fluorescence microscopy, and the incidence of apoptotic granulosa cells was tabulated.
Granulosa cells in the older women revealed a significant increase in the number of apoptotic cells. The number of total oocytes and the number of mature oocytes obtained significantly decreased with age. However, endometrial thickness and follicular estradiol, progesterone, and free testosterone levels were not significantly different among four different age groups.
Age increases apoptotic changes in granulosa cells and consequently decreases the ovarian fecundity.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1023/A:1009422323306</identifier><identifier>PMID: 10911578</identifier><identifier>CODEN: JARGE4</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Adult ; Age groups ; Ageing, cell death ; Aging ; Aging - metabolism ; Apoptosis ; Biological and medical sciences ; Cell death ; Cell physiology ; Endometrium - anatomy & histology ; Estradiol - analysis ; Female ; Fertility - physiology ; Follicles ; Follicular Fluid - chemistry ; Fundamental and applied biological sciences. Psychology ; Granulosa Cells - physiology ; Humans ; In vitro fertilization ; Infertility ; Liver ; Male ; Menstruation ; Molecular and cellular biology ; Morphology ; Oocytes - cytology ; Ovaries ; Patients ; Physiology ; Progesterone - analysis ; Testosterone - analysis ; Tumors</subject><ispartof>Journal of assisted reproduction and genetics, 2000-03, Vol.17 (3), p.168-173</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Mar 2000</rights><rights>Plenum Publishing Corporation 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-bc372f03295336c17084545d3c57291ffcc119b066f07e099c6d9ac591b2b96b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455660/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455660/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1465004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10911578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEYED HOMAYOON SADRAIE</creatorcontrib><creatorcontrib>SAITO, H</creatorcontrib><creatorcontrib>KANEKO, T</creatorcontrib><creatorcontrib>SAITO, T</creatorcontrib><creatorcontrib>HIROI, M</creatorcontrib><title>Effects of aging on ovarian fecundity in terms of the incidence of apoptotic Granulosa cells</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>The objective was to determine the effects of women's age on the ovarian fecundity as assessed by the incidence of apoptotic granulosa cells.
Twenty-eight normo-ovulatory women underwent ovulation induction for standard IVF. The husbands of these women showed severe male infertility factors. The women were divided into four groups according to their ages. Women underwent follicle aspiration after the administration of human menopausal gonadotropin plus human chorionic gonadotropin. The nuclei of granulosa cells were examined by using fluorescence microscopy, and the incidence of apoptotic granulosa cells was tabulated.
Granulosa cells in the older women revealed a significant increase in the number of apoptotic cells. The number of total oocytes and the number of mature oocytes obtained significantly decreased with age. However, endometrial thickness and follicular estradiol, progesterone, and free testosterone levels were not significantly different among four different age groups.
Age increases apoptotic changes in granulosa cells and consequently decreases the ovarian fecundity.</description><subject>Adult</subject><subject>Age groups</subject><subject>Ageing, cell death</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell death</subject><subject>Cell physiology</subject><subject>Endometrium - anatomy & histology</subject><subject>Estradiol - analysis</subject><subject>Female</subject><subject>Fertility - physiology</subject><subject>Follicles</subject><subject>Follicular Fluid - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Granulosa Cells - physiology</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Liver</subject><subject>Male</subject><subject>Menstruation</subject><subject>Molecular and cellular biology</subject><subject>Morphology</subject><subject>Oocytes - cytology</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Physiology</subject><subject>Progesterone - analysis</subject><subject>Testosterone - analysis</subject><subject>Tumors</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0N1LHDEQAPBQKr3T9rlvJZTi2-rkczc-CCKnFQ58sW-FJZtN7nLsJecmK_jfN9rTap8yw_wyzAxCXwmcEKDs9OKMAChOKaOMgfyA5kTUrKpL8rHEIJoKuGxm6DClDRTaUPYJzQgoUmAzR78XzlmTE44O65UPKxwDjg969DrgUplC7_Mj9gFnO26fWV7bkhvf22Ds879d3OWYvcHXow7TEJPGxg5D-owOnB6S_bJ_j9Cvq8Xd5c9qeXt9c3mxrAwXJFedYTV1wKgSjElDami44KJnRtRUEeeMIUR1IKWD2oJSRvZKG6FIRzslO3aEzv_23U3d1vbGhjzqod2NfqvHxzZq376vBL9uV_GhZVwIKaE0ON43GOP9ZFNutz49raCDjVNqa0J5w6Eu8Pt_cBOnMZTlWkqkLAxIQd_ejvM6x8vVC_ixBzoZPbhyNePTP8elAODsD2idkJU</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>SEYED HOMAYOON SADRAIE</creator><creator>SAITO, H</creator><creator>KANEKO, T</creator><creator>SAITO, T</creator><creator>HIROI, M</creator><general>Kluwer/Plenum</general><general>Springer Nature B.V</general><general>Kluwer Academic Publishers-Plenum Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000301</creationdate><title>Effects of aging on ovarian fecundity in terms of the incidence of apoptotic Granulosa cells</title><author>SEYED HOMAYOON SADRAIE ; SAITO, H ; KANEKO, T ; SAITO, T ; HIROI, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-bc372f03295336c17084545d3c57291ffcc119b066f07e099c6d9ac591b2b96b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Age groups</topic><topic>Ageing, cell death</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cell death</topic><topic>Cell physiology</topic><topic>Endometrium - anatomy & histology</topic><topic>Estradiol - analysis</topic><topic>Female</topic><topic>Fertility - physiology</topic><topic>Follicles</topic><topic>Follicular Fluid - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Granulosa Cells - physiology</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Liver</topic><topic>Male</topic><topic>Menstruation</topic><topic>Molecular and cellular biology</topic><topic>Morphology</topic><topic>Oocytes - cytology</topic><topic>Ovaries</topic><topic>Patients</topic><topic>Physiology</topic><topic>Progesterone - analysis</topic><topic>Testosterone - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEYED HOMAYOON SADRAIE</creatorcontrib><creatorcontrib>SAITO, H</creatorcontrib><creatorcontrib>KANEKO, T</creatorcontrib><creatorcontrib>SAITO, T</creatorcontrib><creatorcontrib>HIROI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEYED HOMAYOON SADRAIE</au><au>SAITO, H</au><au>KANEKO, T</au><au>SAITO, T</au><au>HIROI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of aging on ovarian fecundity in terms of the incidence of apoptotic Granulosa cells</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>17</volume><issue>3</issue><spage>168</spage><epage>173</epage><pages>168-173</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><coden>JARGE4</coden><abstract>The objective was to determine the effects of women's age on the ovarian fecundity as assessed by the incidence of apoptotic granulosa cells.
Twenty-eight normo-ovulatory women underwent ovulation induction for standard IVF. The husbands of these women showed severe male infertility factors. The women were divided into four groups according to their ages. Women underwent follicle aspiration after the administration of human menopausal gonadotropin plus human chorionic gonadotropin. The nuclei of granulosa cells were examined by using fluorescence microscopy, and the incidence of apoptotic granulosa cells was tabulated.
Granulosa cells in the older women revealed a significant increase in the number of apoptotic cells. The number of total oocytes and the number of mature oocytes obtained significantly decreased with age. However, endometrial thickness and follicular estradiol, progesterone, and free testosterone levels were not significantly different among four different age groups.
Age increases apoptotic changes in granulosa cells and consequently decreases the ovarian fecundity.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>10911578</pmid><doi>10.1023/A:1009422323306</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2000-03, Vol.17 (3), p.168-173 |
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| subjects | Adult Age groups Ageing, cell death Aging Aging - metabolism Apoptosis Biological and medical sciences Cell death Cell physiology Endometrium - anatomy & histology Estradiol - analysis Female Fertility - physiology Follicles Follicular Fluid - chemistry Fundamental and applied biological sciences. Psychology Granulosa Cells - physiology Humans In vitro fertilization Infertility Liver Male Menstruation Molecular and cellular biology Morphology Oocytes - cytology Ovaries Patients Physiology Progesterone - analysis Testosterone - analysis Tumors |
| title | Effects of aging on ovarian fecundity in terms of the incidence of apoptotic Granulosa cells |
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