Tissue perfusion essential for spermatogenesis and outcome of testicular sperm extraction (TESE) for assisted reproduction
In order to determine if there are areas of major and minor perfusion in a single testicle and if the quality of sperm is correlated with quantity of perfusion we collected testicle tissue for TESE in accordance to the local testicle tissue perfusion. A patient undergoing TESE underwent testicular p...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2004-05, Vol.21 (5), p.175-180 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Herwig, R Tosun, K Pinggera, G M Soelder, E Moeller, K T Pallwein, L Frauscher, E Bartsch, G Wildt, L Illmensee, K |
| description | In order to determine if there are areas of major and minor perfusion in a single testicle and if the quality of sperm is correlated with quantity of perfusion we collected testicle tissue for TESE in accordance to the local testicle tissue perfusion.
A patient undergoing TESE underwent testicular perfusion mapping using contrast enhanced ultrasound. The exposed tissue was scanned with a Laser Doppler scanner and perfusion rates were determined measuring tissue perfusion units (TPUs). Tissue was biopsied and sperm were selected and prepared for assisted reproduction.
The total amount of isolated sperm correlated highly with the intensity of tissue perfusion showing high number of sperm in areas with high TPUs.
This is the first demonstration that sperm quality and quantity is depending on tissue perfusion within the testicle. To further improve infertility treatment we propose that random biopsies could be replaced by perfusion-dependent collection of testicular tissue. |
| doi_str_mv | 10.1023/b:jarg.0000031251.57848.04 |
| format | Article |
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A patient undergoing TESE underwent testicular perfusion mapping using contrast enhanced ultrasound. The exposed tissue was scanned with a Laser Doppler scanner and perfusion rates were determined measuring tissue perfusion units (TPUs). Tissue was biopsied and sperm were selected and prepared for assisted reproduction.
The total amount of isolated sperm correlated highly with the intensity of tissue perfusion showing high number of sperm in areas with high TPUs.
This is the first demonstration that sperm quality and quantity is depending on tissue perfusion within the testicle. To further improve infertility treatment we propose that random biopsies could be replaced by perfusion-dependent collection of testicular tissue.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1023/b:jarg.0000031251.57848.04</identifier><identifier>PMID: 15279325</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Biopsy ; Embryos ; Female ; Humans ; Infertility, Male - therapy ; Lasers ; Male ; Mineral oils ; Morphology ; Oocytes - metabolism ; Ovulation Induction ; Patients ; Perfusion ; Reproductive Techniques, Assisted ; Reproductive technologies ; Sperm ; Sperm Injections, Intracytoplasmic - methods ; Spermatogenesis ; Spermatozoa - cytology ; Spermatozoa - pathology ; Testicular Diseases - therapy ; Testis - diagnostic imaging ; Ultrasonic imaging ; Ultrasonography ; Ultrasonography, Doppler</subject><ispartof>Journal of assisted reproduction and genetics, 2004-05, Vol.21 (5), p.175-180</ispartof><rights>Copyright Kluwer Academic Publishers May 2004</rights><rights>Plenum Publishing Corporation 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-a4bf39c1c3f161a8156e748c938902d630e9d973c9b925d6637cefde1664dacf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455528/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455528/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15279325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herwig, R</creatorcontrib><creatorcontrib>Tosun, K</creatorcontrib><creatorcontrib>Pinggera, G M</creatorcontrib><creatorcontrib>Soelder, E</creatorcontrib><creatorcontrib>Moeller, K T</creatorcontrib><creatorcontrib>Pallwein, L</creatorcontrib><creatorcontrib>Frauscher, E</creatorcontrib><creatorcontrib>Bartsch, G</creatorcontrib><creatorcontrib>Wildt, L</creatorcontrib><creatorcontrib>Illmensee, K</creatorcontrib><title>Tissue perfusion essential for spermatogenesis and outcome of testicular sperm extraction (TESE) for assisted reproduction</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>In order to determine if there are areas of major and minor perfusion in a single testicle and if the quality of sperm is correlated with quantity of perfusion we collected testicle tissue for TESE in accordance to the local testicle tissue perfusion.
A patient undergoing TESE underwent testicular perfusion mapping using contrast enhanced ultrasound. The exposed tissue was scanned with a Laser Doppler scanner and perfusion rates were determined measuring tissue perfusion units (TPUs). Tissue was biopsied and sperm were selected and prepared for assisted reproduction.
The total amount of isolated sperm correlated highly with the intensity of tissue perfusion showing high number of sperm in areas with high TPUs.
This is the first demonstration that sperm quality and quantity is depending on tissue perfusion within the testicle. To further improve infertility treatment we propose that random biopsies could be replaced by perfusion-dependent collection of testicular tissue.</description><subject>Biopsy</subject><subject>Embryos</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility, Male - therapy</subject><subject>Lasers</subject><subject>Male</subject><subject>Mineral oils</subject><subject>Morphology</subject><subject>Oocytes - metabolism</subject><subject>Ovulation Induction</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Reproductive Techniques, Assisted</subject><subject>Reproductive technologies</subject><subject>Sperm</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><subject>Spermatogenesis</subject><subject>Spermatozoa - cytology</subject><subject>Spermatozoa - pathology</subject><subject>Testicular Diseases - therapy</subject><subject>Testis - diagnostic imaging</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasonography, Doppler</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtvEzEUhS1ERUvgLyCrCwSLCX57pgukUoU-VAkJwtpy7DthoplxantQy6_HSSMKeGNL95xP9_ggdErJnBLGP6zONjau52R3OGWSzqWuRT0n4hk6oVLzSnNOnpc3kXVFhKqP0cuUNkXe1Iy_QMdUMt1wJk_Qr2WX0gR4C7GdUhdGDCnBmDvb4zZEnMpgsDmsYYTUJWxHj8OUXRgAhxZnSLlzU28PSgz3OVqXd6B3y8W3xfs9xabizeBxhG0MftoLXqGj1vYJXh_uGfr-ebG8uKpuv1xeX5zfVk5qlisrVi1vHHW8pYramkoFWtSu4XVDmFecQOMbzV2zapj0SnHtoPVAlRLeupbP0MdH7nZaDeBdSRdtb7axG2x8MMF25t_J2P0w6_DTcCGlZHUBvD0AYribSmIzdMlB39sRwpSMUlpyWX52hk7_E27CFMcSzrCyDiOiFDZDZ48iF0NKEdo_m1Bidv2aT-bm_OuleerX7Ps1RBTzm7-zPFkPhfLf8cumBQ</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Herwig, R</creator><creator>Tosun, K</creator><creator>Pinggera, G M</creator><creator>Soelder, E</creator><creator>Moeller, K T</creator><creator>Pallwein, L</creator><creator>Frauscher, E</creator><creator>Bartsch, G</creator><creator>Wildt, L</creator><creator>Illmensee, K</creator><general>Springer Nature B.V</general><general>Kluwer Academic Publishers-Plenum Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200405</creationdate><title>Tissue perfusion essential for spermatogenesis and outcome of testicular sperm extraction (TESE) for assisted reproduction</title><author>Herwig, R ; Tosun, K ; Pinggera, G M ; Soelder, E ; Moeller, K T ; Pallwein, L ; Frauscher, E ; Bartsch, G ; Wildt, L ; Illmensee, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-a4bf39c1c3f161a8156e748c938902d630e9d973c9b925d6637cefde1664dacf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biopsy</topic><topic>Embryos</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility, Male - therapy</topic><topic>Lasers</topic><topic>Male</topic><topic>Mineral oils</topic><topic>Morphology</topic><topic>Oocytes - metabolism</topic><topic>Ovulation Induction</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Reproductive Techniques, Assisted</topic><topic>Reproductive technologies</topic><topic>Sperm</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><topic>Spermatogenesis</topic><topic>Spermatozoa - cytology</topic><topic>Spermatozoa - pathology</topic><topic>Testicular Diseases - therapy</topic><topic>Testis - diagnostic imaging</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herwig, R</creatorcontrib><creatorcontrib>Tosun, K</creatorcontrib><creatorcontrib>Pinggera, G M</creatorcontrib><creatorcontrib>Soelder, E</creatorcontrib><creatorcontrib>Moeller, K T</creatorcontrib><creatorcontrib>Pallwein, L</creatorcontrib><creatorcontrib>Frauscher, E</creatorcontrib><creatorcontrib>Bartsch, G</creatorcontrib><creatorcontrib>Wildt, L</creatorcontrib><creatorcontrib>Illmensee, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herwig, R</au><au>Tosun, K</au><au>Pinggera, G M</au><au>Soelder, E</au><au>Moeller, K T</au><au>Pallwein, L</au><au>Frauscher, E</au><au>Bartsch, G</au><au>Wildt, L</au><au>Illmensee, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue perfusion essential for spermatogenesis and outcome of testicular sperm extraction (TESE) for assisted reproduction</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>2004-05</date><risdate>2004</risdate><volume>21</volume><issue>5</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>In order to determine if there are areas of major and minor perfusion in a single testicle and if the quality of sperm is correlated with quantity of perfusion we collected testicle tissue for TESE in accordance to the local testicle tissue perfusion.
A patient undergoing TESE underwent testicular perfusion mapping using contrast enhanced ultrasound. The exposed tissue was scanned with a Laser Doppler scanner and perfusion rates were determined measuring tissue perfusion units (TPUs). Tissue was biopsied and sperm were selected and prepared for assisted reproduction.
The total amount of isolated sperm correlated highly with the intensity of tissue perfusion showing high number of sperm in areas with high TPUs.
This is the first demonstration that sperm quality and quantity is depending on tissue perfusion within the testicle. To further improve infertility treatment we propose that random biopsies could be replaced by perfusion-dependent collection of testicular tissue.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>15279325</pmid><doi>10.1023/b:jarg.0000031251.57848.04</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2004-05, Vol.21 (5), p.175-180 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3455528 |
| source | MEDLINE; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Biopsy Embryos Female Humans Infertility, Male - therapy Lasers Male Mineral oils Morphology Oocytes - metabolism Ovulation Induction Patients Perfusion Reproductive Techniques, Assisted Reproductive technologies Sperm Sperm Injections, Intracytoplasmic - methods Spermatogenesis Spermatozoa - cytology Spermatozoa - pathology Testicular Diseases - therapy Testis - diagnostic imaging Ultrasonic imaging Ultrasonography Ultrasonography, Doppler |
| title | Tissue perfusion essential for spermatogenesis and outcome of testicular sperm extraction (TESE) for assisted reproduction |
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