Outcome of IVF in DES-exposed daughters : Experience in the 90s
The outcome of in vitro fertilization (IVF) in a group of infertile women with a history of in utero exposure to diethylstilbestrol (DES) was analyzed. Records from an academic IVF program were retrospectively reviewed. Seventeen infertile women with a self-reported history of exposure to DES in ute...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 1997-10, Vol.14 (9), p.513-517 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | PAL, L SHIFREN, J. L ISAACSON, K. B CHANG, Y MAREAN, M LEYKIN, L TOTH, T. L |
| description | The outcome of in vitro fertilization (IVF) in a group of infertile women with a history of in utero exposure to diethylstilbestrol (DES) was analyzed. Records from an academic IVF program were retrospectively reviewed.
Seventeen infertile women with a self-reported history of exposure to DES in utero, attending the IVF unit at Massachusetts General Hospital (MGH) for assisted reproductive technology (ART), underwent 27 IVF cycles. Analysis of the outcome of IVF including implantation and ongoing pregnancy rates was performed. The data were compared with results from a group of 20 infertile patients with idiopathic infertility undergoing 27 IVF cycles at MGH during the same period. The patients in the two groups were matched for age, basal day 3 levels of follicle stimulating hormone and serum estradiol, and the number and quality of embryos transferred.
The response to controlled ovarian hyperstimulation was comparable in the two groups. Significantly lower implantation and ongoing pregnancy rates following IVF and embryo transfer were seen in the utero DES-exposed group compared to the control patients.
Infertile patients with a history of in utero exposure to DES exhibit a significantly impaired implantation rate following IVF, and the outcome of ART remains poor. |
| doi_str_mv | 10.1023/A:1021175326230 |
| format | Article |
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Seventeen infertile women with a self-reported history of exposure to DES in utero, attending the IVF unit at Massachusetts General Hospital (MGH) for assisted reproductive technology (ART), underwent 27 IVF cycles. Analysis of the outcome of IVF including implantation and ongoing pregnancy rates was performed. The data were compared with results from a group of 20 infertile patients with idiopathic infertility undergoing 27 IVF cycles at MGH during the same period. The patients in the two groups were matched for age, basal day 3 levels of follicle stimulating hormone and serum estradiol, and the number and quality of embryos transferred.
The response to controlled ovarian hyperstimulation was comparable in the two groups. Significantly lower implantation and ongoing pregnancy rates following IVF and embryo transfer were seen in the utero DES-exposed group compared to the control patients.
Infertile patients with a history of in utero exposure to DES exhibit a significantly impaired implantation rate following IVF, and the outcome of ART remains poor.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1023/A:1021175326230</identifier><identifier>PMID: 9401869</identifier><identifier>CODEN: JARGE4</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; Diethylstilbestrol - adverse effects ; Diethylstilbestrol - pharmacology ; Embryo Implantation - drug effects ; Estradiol - blood ; Estrogens, Non-Steroidal - adverse effects ; Estrogens, Non-Steroidal - pharmacology ; Female ; Fertilization in Vitro - methods ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Pregnancy ; Pregnancy Rate ; Prenatal Exposure Delayed Effects ; Retrospective Studies ; Sterility. Assisted procreation ; Treatment Outcome</subject><ispartof>Journal of assisted reproduction and genetics, 1997-10, Vol.14 (9), p.513-517</ispartof><rights>1998 INIST-CNRS</rights><rights>Plenum Publishing Corporation 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-87b123773d4de9c4bc3dcd5c414ed3ee061c3e60b3cf42e592094fbd25c7c17b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454843/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454843/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2118204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9401869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAL, L</creatorcontrib><creatorcontrib>SHIFREN, J. L</creatorcontrib><creatorcontrib>ISAACSON, K. B</creatorcontrib><creatorcontrib>CHANG, Y</creatorcontrib><creatorcontrib>MAREAN, M</creatorcontrib><creatorcontrib>LEYKIN, L</creatorcontrib><creatorcontrib>TOTH, T. L</creatorcontrib><title>Outcome of IVF in DES-exposed daughters : Experience in the 90s</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>The outcome of in vitro fertilization (IVF) in a group of infertile women with a history of in utero exposure to diethylstilbestrol (DES) was analyzed. Records from an academic IVF program were retrospectively reviewed.
Seventeen infertile women with a self-reported history of exposure to DES in utero, attending the IVF unit at Massachusetts General Hospital (MGH) for assisted reproductive technology (ART), underwent 27 IVF cycles. Analysis of the outcome of IVF including implantation and ongoing pregnancy rates was performed. The data were compared with results from a group of 20 infertile patients with idiopathic infertility undergoing 27 IVF cycles at MGH during the same period. The patients in the two groups were matched for age, basal day 3 levels of follicle stimulating hormone and serum estradiol, and the number and quality of embryos transferred.
The response to controlled ovarian hyperstimulation was comparable in the two groups. Significantly lower implantation and ongoing pregnancy rates following IVF and embryo transfer were seen in the utero DES-exposed group compared to the control patients.
Infertile patients with a history of in utero exposure to DES exhibit a significantly impaired implantation rate following IVF, and the outcome of ART remains poor.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Diethylstilbestrol - adverse effects</subject><subject>Diethylstilbestrol - pharmacology</subject><subject>Embryo Implantation - drug effects</subject><subject>Estradiol - blood</subject><subject>Estrogens, Non-Steroidal - adverse effects</subject><subject>Estrogens, Non-Steroidal - pharmacology</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Retrospective Studies</subject><subject>Sterility. Assisted procreation</subject><subject>Treatment Outcome</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1PwkAUxDdGg4iePZnswWv17b5tt-WgIQhKQsLBj2uz3X2FGmibbiH431sjIXqaSWbmdxjGrgXcCZB4Pxp2IoQOUUYS4YT1Ragx0Ihw2nkI4wBUFJ-zC-8_ASCJJfZYL1Eg4ijps8fFtrXVhniV89nHlBclf5q8BrSvK0-OO7NdrlpqPB_yyb6mpqDS0k-rXRFPwF-ys9ysPV0ddMDep5O38UswXzzPxqN5YFHrNoh1JmTn0ClHiVWZRWddaJVQ5JAIImGRIsjQ5kpSmEhIVJ45GVpthc5wwB5-ufU225CzVLaNWad1U2xM85VWpkj_J2WxSpfVLkUVqlhhB7j5CzguD090-e0hN96add6Y0hb-WOs-jiUo_AZhAWw9</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>PAL, L</creator><creator>SHIFREN, J. L</creator><creator>ISAACSON, K. B</creator><creator>CHANG, Y</creator><creator>MAREAN, M</creator><creator>LEYKIN, L</creator><creator>TOTH, T. L</creator><general>Kluwer/Plenum</general><general>Kluwer Academic Publishers-Plenum Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19971001</creationdate><title>Outcome of IVF in DES-exposed daughters : Experience in the 90s</title><author>PAL, L ; SHIFREN, J. L ; ISAACSON, K. B ; CHANG, Y ; MAREAN, M ; LEYKIN, L ; TOTH, T. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-87b123773d4de9c4bc3dcd5c414ed3ee061c3e60b3cf42e592094fbd25c7c17b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Diethylstilbestrol - adverse effects</topic><topic>Diethylstilbestrol - pharmacology</topic><topic>Embryo Implantation - drug effects</topic><topic>Estradiol - blood</topic><topic>Estrogens, Non-Steroidal - adverse effects</topic><topic>Estrogens, Non-Steroidal - pharmacology</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Retrospective Studies</topic><topic>Sterility. Assisted procreation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAL, L</creatorcontrib><creatorcontrib>SHIFREN, J. L</creatorcontrib><creatorcontrib>ISAACSON, K. B</creatorcontrib><creatorcontrib>CHANG, Y</creatorcontrib><creatorcontrib>MAREAN, M</creatorcontrib><creatorcontrib>LEYKIN, L</creatorcontrib><creatorcontrib>TOTH, T. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PAL, L</au><au>SHIFREN, J. L</au><au>ISAACSON, K. B</au><au>CHANG, Y</au><au>MAREAN, M</au><au>LEYKIN, L</au><au>TOTH, T. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome of IVF in DES-exposed daughters : Experience in the 90s</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>14</volume><issue>9</issue><spage>513</spage><epage>517</epage><pages>513-517</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><coden>JARGE4</coden><abstract>The outcome of in vitro fertilization (IVF) in a group of infertile women with a history of in utero exposure to diethylstilbestrol (DES) was analyzed. Records from an academic IVF program were retrospectively reviewed.
Seventeen infertile women with a self-reported history of exposure to DES in utero, attending the IVF unit at Massachusetts General Hospital (MGH) for assisted reproductive technology (ART), underwent 27 IVF cycles. Analysis of the outcome of IVF including implantation and ongoing pregnancy rates was performed. The data were compared with results from a group of 20 infertile patients with idiopathic infertility undergoing 27 IVF cycles at MGH during the same period. The patients in the two groups were matched for age, basal day 3 levels of follicle stimulating hormone and serum estradiol, and the number and quality of embryos transferred.
The response to controlled ovarian hyperstimulation was comparable in the two groups. Significantly lower implantation and ongoing pregnancy rates following IVF and embryo transfer were seen in the utero DES-exposed group compared to the control patients.
Infertile patients with a history of in utero exposure to DES exhibit a significantly impaired implantation rate following IVF, and the outcome of ART remains poor.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>9401869</pmid><doi>10.1023/A:1021175326230</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 1997-10, Vol.14 (9), p.513-517 |
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| source | MEDLINE; SpringerNature Journals; PubMed Central |
| subjects | Adult Biological and medical sciences Birth control Diethylstilbestrol - adverse effects Diethylstilbestrol - pharmacology Embryo Implantation - drug effects Estradiol - blood Estrogens, Non-Steroidal - adverse effects Estrogens, Non-Steroidal - pharmacology Female Fertilization in Vitro - methods Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans Medical sciences Pregnancy Pregnancy Rate Prenatal Exposure Delayed Effects Retrospective Studies Sterility. Assisted procreation Treatment Outcome |
| title | Outcome of IVF in DES-exposed daughters : Experience in the 90s |
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