Inhibition of 3-hydroxy-3-methylglutaryl-CoA Reductase by Mevinolin in Familial Hypercholesterolemia Heterozygotes: Effects on Cholesterol Balance

Patients with heterozygous familial hypercholesterolemia (FH) have a deficiency of receptors for plasma low-density lipoprotein (LDL) that impairs removal of LDL from plasma. In these patients, mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase [mevalonate: NAD+oxidoreductase (CoA-a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-04, Vol.81 (8), p.2538-2542
Hauptverfasser:	Grundy, Scott M., Bilheimer, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cells Cholesterol - blood Cholesterol, Dietary Cholesterols Clinical Trials as Topic Excretion Heterozygote Heterozygotes Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - drug therapy LDL receptors Lipids Lipoproteins Liver cells Lovastatin Naphthalenes - therapeutic use Placebos Steroids Time Factors Triglycerides - blood
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