Incidence and potential implications of the toxic metabolite methylglyoxal in cell culture : A review

Methylglyoxal is a toxic metabolite unavoidably produced in mammalian systems as a by-product of glycolysis. Detoxification of this compound occurs principally through the glyoxalase pathway, which consists of glyoxalase I and glyoxalase II, and requires reduced glutathione as a co-enzyme. Recently,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cytotechnology (Dordrecht) 1998-05, Vol.26 (3), p.173-183
1. Verfasser:	CHAPLEN, F. W. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Animal cells Apoptosis Biological and medical sciences Biotechnology Cell culture Cell viability Culture media Cysteine Detoxification Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Gene expression Genotoxicity Glutamine Glutathione Glycolysis Hydroxyacylglutathione hydrolase Lactoylglutathione lyase Lysine Methods. Procedures. Technologies Miscellaneous Physiology Point mutation Pyruvaldehyde Serum levels
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!