DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations
ICF syndrome is a rare autosomal recessive disorder that is characterized by Immunodeficiency, Centromeric instability, and Facial anomalies. In all, 60% of ICF patients have mutations in the DNMT3B (DNA methyltransferase 3B) gene, encoding a de novo DNA methyltransferase. In ICF cells, constitutive...
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| Veröffentlicht in: | European journal of human genetics : EJHG 2012-10, Vol.20 (10), p.1044-1050 |
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| description | ICF syndrome is a rare autosomal recessive disorder that is characterized by Immunodeficiency, Centromeric instability, and Facial anomalies. In all, 60% of ICF patients have mutations in the DNMT3B (DNA methyltransferase 3B) gene, encoding a de novo DNA methyltransferase. In ICF cells, constitutive heterochromatin is hypomethylated and decondensed, metaphase chromosomes undergo rearrangements (mainly involving juxtacentromeric regions), and more than 700 genes are aberrantly expressed. This work shows that DNA replication is also altered in ICF cells: (i) heterochromatic genes replicate earlier in the S-phase; (ii) global replication fork speed is higher; and (iii) S-phase is shorter. These replication defects may result from chromatin changes that modify DNA accessibility to the replication machinery and/or from changes in the expression level of genes involved in DNA replication. This work highlights the interest of using ICF cells as a model to investigate how DNA methylation regulates DNA replication in humans. |
| doi_str_mv | 10.1038/ejhg.2012.41 |
| format | Article |
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In all, 60% of ICF patients have mutations in the DNMT3B (DNA methyltransferase 3B) gene, encoding a de novo DNA methyltransferase. In ICF cells, constitutive heterochromatin is hypomethylated and decondensed, metaphase chromosomes undergo rearrangements (mainly involving juxtacentromeric regions), and more than 700 genes are aberrantly expressed. This work shows that DNA replication is also altered in ICF cells: (i) heterochromatic genes replicate earlier in the S-phase; (ii) global replication fork speed is higher; and (iii) S-phase is shorter. These replication defects may result from chromatin changes that modify DNA accessibility to the replication machinery and/or from changes in the expression level of genes involved in DNA replication. This work highlights the interest of using ICF cells as a model to investigate how DNA methylation regulates DNA replication in humans.</description><identifier>ISSN: 1018-4813</identifier><identifier>EISSN: 1476-5438</identifier><identifier>DOI: 10.1038/ejhg.2012.41</identifier><identifier>PMID: 22378288</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Biological and medical sciences ; Cancer ; Cell Line ; Chromatin ; Chromosomes ; Deoxyribonucleic acid ; DNA ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA biosynthesis ; DNA methylation ; DNA methyltransferase ; DNA Methyltransferase 3B ; Epigenetics ; Face - abnormalities ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; Genomics ; Hereditary diseases ; Heterochromatin ; Heterochromatin - genetics ; Humans ; ICF syndrome ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunodeficiency ; Immunologic Deficiency Syndromes - genetics ; Immunopathology ; Life Sciences ; Medical genetics ; Medical sciences ; Metaphase ; Methylation ; Molecular and cellular biology ; Mutation ; Mutation, Missense ; Neurogenesis ; Patients ; Primary Immunodeficiency Diseases ; Replication ; Replication forks ; S Phase - genetics ; Satellites</subject><ispartof>European journal of human genetics : EJHG, 2012-10, Vol.20 (10), p.1044-1050</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2012</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2012 Macmillan Publishers Limited 2012 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-ca038e19a82ae284bdddc212e6a012abc503be2dd9aec159da75b4677ba3c9833</citedby><cites>FETCH-LOGICAL-c575t-ca038e19a82ae284bdddc212e6a012abc503be2dd9aec159da75b4677ba3c9833</cites><orcidid>0000-0002-9997-1645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449075/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449075/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26389470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22378288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-02444088$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>LANA, Erica</creatorcontrib><creatorcontrib>MEGARBANE, Andre</creatorcontrib><creatorcontrib>TOURRIERE, Helene</creatorcontrib><creatorcontrib>SARDA, Pierre</creatorcontrib><creatorcontrib>LEFRANC, Gerard</creatorcontrib><creatorcontrib>CLAUSTRES, Mireille</creatorcontrib><creatorcontrib>DE SARIO, Albertina</creatorcontrib><title>DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations</title><title>European journal of human genetics : EJHG</title><addtitle>Eur J Hum Genet</addtitle><description>ICF syndrome is a rare autosomal recessive disorder that is characterized by Immunodeficiency, Centromeric instability, and Facial anomalies. In all, 60% of ICF patients have mutations in the DNMT3B (DNA methyltransferase 3B) gene, encoding a de novo DNA methyltransferase. In ICF cells, constitutive heterochromatin is hypomethylated and decondensed, metaphase chromosomes undergo rearrangements (mainly involving juxtacentromeric regions), and more than 700 genes are aberrantly expressed. This work shows that DNA replication is also altered in ICF cells: (i) heterochromatic genes replicate earlier in the S-phase; (ii) global replication fork speed is higher; and (iii) S-phase is shorter. These replication defects may result from chromatin changes that modify DNA accessibility to the replication machinery and/or from changes in the expression level of genes involved in DNA replication. This work highlights the interest of using ICF cells as a model to investigate how DNA methylation regulates DNA replication in humans.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Chromatin</subject><subject>Chromosomes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA (Cytosine-5-)-Methyltransferases - genetics</subject><subject>DNA biosynthesis</subject><subject>DNA methylation</subject><subject>DNA methyltransferase</subject><subject>DNA Methyltransferase 3B</subject><subject>Epigenetics</subject><subject>Face - abnormalities</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hereditary diseases</subject><subject>Heterochromatin</subject><subject>Heterochromatin - genetics</subject><subject>Humans</subject><subject>ICF syndrome</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunodeficiency</subject><subject>Immunologic Deficiency Syndromes - genetics</subject><subject>Immunopathology</subject><subject>Life Sciences</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Metaphase</subject><subject>Methylation</subject><subject>Molecular and cellular biology</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Neurogenesis</subject><subject>Patients</subject><subject>Primary Immunodeficiency Diseases</subject><subject>Replication</subject><subject>Replication forks</subject><subject>S Phase - genetics</subject><subject>Satellites</subject><issn>1018-4813</issn><issn>1476-5438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks9v0zAUxyMEYmNw44wsIaRNIsW_EjsXpNJRVqmMyzhbL47bunKczk4m9bD_fQ4tA3biZMvfj7_P7_mbZW8JnhDM5Cez3awnFBM64eRZdkq4KPOCM_k87TGROZeEnWSvYtxinERBXmYnlDIhqZSn2f3l9RQFs3NWQ287j2xE4HoTTIOsR4u2HXzXmJXV1ni9RzPj-9C1Jlid9NhDbZ3t92gO2oJD4LsWnDURnS9m8wukjXMRaQhhb_0aXV5_v2FfUDv0v4rF19mLFbho3hzXs-zn_OvN7Cpf_vi2mE2XuS5E0ecaUqOGVCApGCp53TSNpoSaElLfUOsCs9rQpqnAaFJUDYii5qUQNTBdScbOss8H391Qt6bRYxPg1C7YFsJedWDVv4q3G7Xu7hTjvMKiSAYXB4PNk2tX06UazzDlnGMp70hiz4_FQnc7mNir1sZxEOBNN0RFcMXSPwhS_AdaVhQXRI6u75-g224IPk0tUZyQklWlTNTHA6VDF2Mwq8fHEqzGuKgxLmqMi-Kj6bu_5_II_85HAj4cAYga3CqA1zb-4UomKy4wewBvAMjI</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>LANA, Erica</creator><creator>MEGARBANE, Andre</creator><creator>TOURRIERE, Helene</creator><creator>SARDA, Pierre</creator><creator>LEFRANC, Gerard</creator><creator>CLAUSTRES, Mireille</creator><creator>DE SARIO, Albertina</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9997-1645</orcidid></search><sort><creationdate>20121001</creationdate><title>DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations</title><author>LANA, Erica ; MEGARBANE, Andre ; TOURRIERE, Helene ; SARDA, Pierre ; LEFRANC, Gerard ; CLAUSTRES, Mireille ; DE SARIO, Albertina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-ca038e19a82ae284bdddc212e6a012abc503be2dd9aec159da75b4677ba3c9833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Chromatin</topic><topic>Chromosomes</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA (Cytosine-5-)-Methyltransferases - genetics</topic><topic>DNA biosynthesis</topic><topic>DNA methylation</topic><topic>DNA methyltransferase</topic><topic>DNA Methyltransferase 3B</topic><topic>Epigenetics</topic><topic>Face - abnormalities</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Hereditary diseases</topic><topic>Heterochromatin</topic><topic>Heterochromatin - genetics</topic><topic>Humans</topic><topic>ICF syndrome</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. 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In all, 60% of ICF patients have mutations in the DNMT3B (DNA methyltransferase 3B) gene, encoding a de novo DNA methyltransferase. In ICF cells, constitutive heterochromatin is hypomethylated and decondensed, metaphase chromosomes undergo rearrangements (mainly involving juxtacentromeric regions), and more than 700 genes are aberrantly expressed. This work shows that DNA replication is also altered in ICF cells: (i) heterochromatic genes replicate earlier in the S-phase; (ii) global replication fork speed is higher; and (iii) S-phase is shorter. These replication defects may result from chromatin changes that modify DNA accessibility to the replication machinery and/or from changes in the expression level of genes involved in DNA replication. This work highlights the interest of using ICF cells as a model to investigate how DNA methylation regulates DNA replication in humans.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>22378288</pmid><doi>10.1038/ejhg.2012.41</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9997-1645</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Cancer Cell Line Chromatin Chromosomes Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA biosynthesis DNA methylation DNA methyltransferase DNA Methyltransferase 3B Epigenetics Face - abnormalities Fundamental and applied biological sciences. Psychology Gene Expression Genetics of eukaryotes. Biological and molecular evolution Genomes Genomics Hereditary diseases Heterochromatin Heterochromatin - genetics Humans ICF syndrome Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunodeficiency Immunologic Deficiency Syndromes - genetics Immunopathology Life Sciences Medical genetics Medical sciences Metaphase Methylation Molecular and cellular biology Mutation Mutation, Missense Neurogenesis Patients Primary Immunodeficiency Diseases Replication Replication forks S Phase - genetics Satellites |
| title | DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations |
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