Glucocorticoid Inhibition of Initiation of Transcription of the DNA Encoding rRNA (rDNA) in Lymphosarcoma P1798 Cells

Cell-free extracts of lymphosarcoma P1798 cell culture lines support faithful initiation upon the cloned mouse DNA encoding rRNA (rDNA) promoter, whereas extracts from cells treated for 16 hr with 0.1μ M dexamethasone cannot. Extracts from both sources transcribe the cloned 5S RNA gene in vitro and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-02, Vol.81 (3), p.718-721
Hauptverfasser:	Cavanaugh, Alice H., Gokal, Preeti K., Lawther, Robert P., Thompson, E. Aubrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell extracts Cell Line Cell lines Cricetinae Dexamethasone - pharmacology DNA DNA - genetics DNA Restriction Enzymes DNA, Ribosomal Genes Genes - drug effects Glucocorticoids Hormonal regulation Lymphoma, Non-Hodgkin - metabolism Mesocricetus Mice Mice, Inbred BALB C Nucleic acids Plasmids Ribosomal DNA RNA RNA Polymerase I - antagonists & inhibitors RNA, Ribosomal - genetics Transcription, Genetic - drug effects
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