Influence of Host Genetics and Environment on Nasal Carriage of Staphylococcus aureus in Danish Middle-Aged and Elderly Twins
Background. Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, onequarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Methods. Nasal swabs were obtained from a national cohort of middle-aged and elderly...
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| Veröffentlicht in: | The Journal of infectious diseases 2012-10, Vol.206 (8), p.1178-1184 |
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| creator | Andersen, Paal Skytt Pedersen, Jacob Krabbe Fode, Peder Skov, Robert L. Fowler, Vance G. Stegger, Marc Christensen, Kaare |
| description | Background. Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, onequarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Methods. Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. Results. The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. Conclusion. In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals. |
| doi_str_mv | 10.1093/infdis/jis491 |
| format | Article |
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Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, onequarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Methods. Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. Results. The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. Conclusion. In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jis491</identifier><identifier>PMID: 22872733</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; BACTERIA ; Bacteriology ; Biological and medical sciences ; Carrier State - epidemiology ; Denmark ; Environmental Microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic concordance ; Genetics ; Heritability ; Humans ; Identical twins ; Infectious diseases ; Major and Brief Reports ; Male ; Medical genetics ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Modeling ; Molecular Typing ; Older adults ; Prevalence ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - genetics ; Staphylococcus aureus ; Staphylococcus aureus - classification ; Staphylococcus aureus - genetics ; Staphylococcus aureus - growth & development ; Staphylococcus aureus - isolation & purification ; Twin studies ; Twins</subject><ispartof>The Journal of infectious diseases, 2012-10, Vol.206 (8), p.1178-1184</ispartof><rights>Copyright © 2012 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><rights>The Author 2012. 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Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, onequarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Methods. Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. Results. The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. Conclusion. In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BACTERIA</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier State - epidemiology</subject><subject>Denmark</subject><subject>Environmental Microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic concordance</subject><subject>Genetics</subject><subject>Heritability</subject><subject>Humans</subject><subject>Identical twins</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Modeling</subject><subject>Molecular Typing</subject><subject>Older adults</subject><subject>Prevalence</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - genetics</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - classification</subject><subject>Staphylococcus aureus - genetics</subject><subject>Staphylococcus aureus - growth & development</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Twin studies</subject><subject>Twins</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTtvFDEUhS0EIiFQUoLcRKIZYo_fDVK0hCRSgIJQW14_dr3y2os9E7QF_50Js6ygusX5zrn36gDwGqP3GClyEXNwsV1sYqMKPwGnmBHRcY7JU3CKUN93WCp1Al60tkEIUcLFc3DS91L0gpBT8Os2hzT6bD0sAd6UNsBrn_0QbYMmO3iVH2IteevzAEuGX0wzCS5MrdGs_li-DWa33qdii7Xj5Bmrn0bM8KPJsa3h5-hc8t3lyrs5MDlf0x7e_4y5vQTPgknNvzrMM_D909X94qa7-3p9u7i86ywlauio8xJbJ7BTinAqDbOB06UMigdjkEIBW8YwC0iwpcGYEOK5RJQJ5qSwjpyBD3PublxuvbPTN9Ukvatxa-peFxP1_0qOa70qD5pQKhVXU8C7Q0AtP0bfBr2NzfqUTPZlbBojiTimSrIJ7WbU1tJa9eG4BiP9WJmeK9NzZRP_9t_bjvTfjibg_ACYZk0K1WQ72Y8cp1j18vHGNzO3aUOpR51i0TNBJPkNSOWs0g</recordid><startdate>20121015</startdate><enddate>20121015</enddate><creator>Andersen, Paal Skytt</creator><creator>Pedersen, Jacob Krabbe</creator><creator>Fode, Peder</creator><creator>Skov, Robert L.</creator><creator>Fowler, Vance G.</creator><creator>Stegger, Marc</creator><creator>Christensen, Kaare</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121015</creationdate><title>Influence of Host Genetics and Environment on Nasal Carriage of Staphylococcus aureus in Danish Middle-Aged and Elderly Twins</title><author>Andersen, Paal Skytt ; Pedersen, Jacob Krabbe ; Fode, Peder ; Skov, Robert L. ; Fowler, Vance G. ; Stegger, Marc ; Christensen, Kaare</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-4de81cd71d993648a5cf64b8f96faa090f1c5515f075ba11333e6804575d87cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BACTERIA</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier State - epidemiology</topic><topic>Denmark</topic><topic>Environmental Microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic concordance</topic><topic>Genetics</topic><topic>Heritability</topic><topic>Humans</topic><topic>Identical twins</topic><topic>Infectious diseases</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Modeling</topic><topic>Molecular Typing</topic><topic>Older adults</topic><topic>Prevalence</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - genetics</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - classification</topic><topic>Staphylococcus aureus - genetics</topic><topic>Staphylococcus aureus - growth & development</topic><topic>Staphylococcus aureus - isolation & purification</topic><topic>Twin studies</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Paal Skytt</creatorcontrib><creatorcontrib>Pedersen, Jacob Krabbe</creatorcontrib><creatorcontrib>Fode, Peder</creatorcontrib><creatorcontrib>Skov, Robert L.</creatorcontrib><creatorcontrib>Fowler, Vance G.</creatorcontrib><creatorcontrib>Stegger, Marc</creatorcontrib><creatorcontrib>Christensen, Kaare</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Paal Skytt</au><au>Pedersen, Jacob Krabbe</au><au>Fode, Peder</au><au>Skov, Robert L.</au><au>Fowler, Vance G.</au><au>Stegger, Marc</au><au>Christensen, Kaare</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Host Genetics and Environment on Nasal Carriage of Staphylococcus aureus in Danish Middle-Aged and Elderly Twins</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2012-10-15</date><risdate>2012</risdate><volume>206</volume><issue>8</issue><spage>1178</spage><epage>1184</epage><pages>1178-1184</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Background. Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, onequarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Methods. Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. Results. The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. Conclusion. In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22872733</pmid><doi>10.1093/infdis/jis491</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over BACTERIA Bacteriology Biological and medical sciences Carrier State - epidemiology Denmark Environmental Microbiology Female Fundamental and applied biological sciences. Psychology Genetic concordance Genetics Heritability Humans Identical twins Infectious diseases Major and Brief Reports Male Medical genetics Medical sciences Microbiology Middle Aged Miscellaneous Modeling Molecular Typing Older adults Prevalence Staphylococcal Infections - epidemiology Staphylococcal Infections - genetics Staphylococcus aureus Staphylococcus aureus - classification Staphylococcus aureus - genetics Staphylococcus aureus - growth & development Staphylococcus aureus - isolation & purification Twin studies Twins |
| title | Influence of Host Genetics and Environment on Nasal Carriage of Staphylococcus aureus in Danish Middle-Aged and Elderly Twins |
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