Ixodes scapularis JAK-STAT Pathway Regulates Tick Antimicrobial Peptides, Thereby Controlling the Agent of Human Granulocytic Anaplasmosis

Ixodes scapularis transmits the agent of human granulocytic anaplasmosis, among other pathogens. The mechanisms used by the tick to control Anaplasma phagocytophilum are not known. We demonstrate that the I. scapularis Janus kinase (JAK)-signaling transducer activator of transcription (STAT) pathway...

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Veröffentlicht in:	The Journal of infectious diseases 2012-10, Vol.206 (8), p.1233-1241
Hauptverfasser:	Liu, Lei, Dai, Jianfeng, Zhao, Yang O., Narasimhan, Sukanya, Yang, Ying, Zhang, Lili, Fikrig, Erol
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplasma phagocytophilum - immunology Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - immunology BACTERIA Biological and medical sciences Cell lines Disease transmission Drosophila Electrophoretic Mobility Shift Assay Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation Hematopoietic stem cells Hemolymph Infections Infectious diseases Ixodes - immunology Ixodes - microbiology Janus Kinase 1 - immunology Major and Brief Reports Medical sciences Microbiology Midgut Pathogens Salivary glands Salivary Glands - immunology Salivary Glands - microbiology Signal Transduction STAT Transcription Factors - immunology Ticks
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