Blockade of β‐adrenoceptors restores the GRK2‐mediated adrenal α2‐adrenoceptor–catecholamine production axis in heart failure

BACKGROUND AND PURPOSE Sympathetic nervous system (SNS) hyperactivity is characteristic of chronic heart failure (HF) and significantly worsens prognosis. The success of β‐adrenoceptor antagonist (β‐blockers) therapy in HF is primarily attributed to protection of the heart from the noxious effects o...

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Veröffentlicht in:	British journal of pharmacology 2012-08, Vol.166 (8), p.2430-2440
Hauptverfasser:	Rengo, G, Lymperopoulos, A, Zincarelli, C, Femminella, GD, Liccardo, D, Pagano, G, de Lucia, C, Cannavo, A, Gargiulo, P, Ferrara, N, Perrone Filardi, P, Koch, WJ, Leosco, D
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenal GRK2 Biological and medical sciences Cardiology. Vascular system catecholamines Heart heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement Medical sciences Pharmacology. Drug treatments Research Papers sympathetic overactivity β‐blocker
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