Assembly and Maintenance of Nodes of Ranvier Rely on Distinct Sources of Proteins and Targeting Mechanisms

We have investigated the source(s) and targeting of components to PNS nodes of Ranvier. We show adhesion molecules are freely diffusible within the axon membrane and accumulate at forming nodes from local sources, whereas ion channels and cytoskeletal components are largely immobile and require tran...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2012-01, Vol.73 (1), p.92-107
Hauptverfasser:	Zhang, Yanqing, Bekku, Yoko, Dzhashiashvili, Yulia, Armenti, Stephen, Meng, Xiaosong, Sasaki, Yo, Milbrandt, Jeffrey, Salzer, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotinylation Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cells, Cultured Coculture Techniques - methods Fluorescence Recovery After Photobleaching - methods Ganglia, Spinal - cytology Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Mice Mice, Transgenic Microscopy, Confocal Models, Biological Myelin Basic Protein - metabolism Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - drug effects Neurons - metabolism Proteins Ranvier's Nodes - physiology Rats Rodents Schwann Cells - physiology Transfection
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