Structural Organization of the Nine Spectrin Repeats of Kalirin

Sequence analysis suggests that KALRN, a Rho GDP/GTP exchange factor genetically linked to schizophrenia, could contain as many as nine tandem spectrin repeats (SRs). We expressed and purified fragments of Kalirin containing from one to five putative SRs to determine whether they formed nested struc...

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Veröffentlicht in:	Biochemistry (Easton) 2012-07, Vol.51 (28), p.5663-5673
Hauptverfasser:	Vishwanatha, K. S, Wang, Y. P, Keutmann, H. T, Mains, R. E, Eipper, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Animals Chromatography, Gel Circular Dichroism circular dichroism spectroscopy denaturation dendrites dystrophin gel chromatography Guanine Nucleotide Exchange Factors - chemistry guanosine triphosphate inducible nitric oxide synthase Models, Molecular Protein Isoforms - chemistry Protein Structure, Secondary Protein Structure, Tertiary Protein Unfolding proteolysis Rats Recombinant Proteins - chemistry Repetitive Sequences, Amino Acid schizophrenia sequence analysis solubility spectrin Ultracentrifugation
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