Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy

Disruption of glandular architecture associates with poor clinical outcome in high-grade colorectal cancer (CRC). Phosphatase and tensin homolog deleted on chromosome ten (PTEN) regulates morphogenic growth of benign MDCK (Madin Darby Canine Kidney) cells through effects on the Rho-like GTPase cdc42...

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Veröffentlicht in:	Oncogene 2013-03, Vol.32 (10), p.1305-1315
Hauptverfasser:	Jagan, I, Fatehullah, A, Deevi, R K, Bingham, V, Campbell, F C
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/136/1660 631/67/1059/602 631/67/1504/1885 Anilides - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Benign Caco-2 Cells Cancer Care and treatment cdc42 GTP-Binding Protein - metabolism Cdc42 protein Cell activation Cell Biology Cell culture Cell division Cell Growth Processes - drug effects Cell Growth Processes - physiology Cell size Chromosomes Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development Epithelium Genetic aspects Glands Guanine Guanine nucleotide exchange factor Guanosinetriphosphatase HCT116 Cells Health aspects Human Genetics Humans Internal Medicine Ligands Localization Madin Darby Canine Kidney Cells Medicine Medicine & Public Health Molecular Targeted Therapy Morphogenesis Nuclear receptors Oncology original-article Peroxisome proliferator-activated receptors Phenotypes PPAR gamma - antagonists & inhibitors PPAR gamma - genetics PPAR gamma - metabolism PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein RNA Rosiglitazone Signal Transduction Tensin Thiazolidinediones - pharmacology Transfection Vacuoles
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