Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans
Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communiti...
Gespeichert in:
| Veröffentlicht in: | The ISME Journal 2012-10, Vol.6 (10), p.1858-1868 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1868 |
|---|---|
| container_issue | 10 |
| container_start_page | 1858 |
| container_title | The ISME Journal |
| container_volume | 6 |
| creator | Sanapareddy, Nina Legge, Ryan M Jovov, Biljana McCoy, Amber Burcal, Lauren Araujo-Perez, Felix Randall, Thomas A Galanko, Joseph Benson, Andrew Sandler, Robert S Rawls, John F Abdo, Zaid Fodor, Anthony A Keku, Temitope O |
| description | Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. |
| doi_str_mv | 10.1038/ismej.2012.43 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3446812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1221140969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-c5072ac0745bdd09efcc077908a0405c54f100095daa4e8700283f4cd9101f63</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhk1padIkx16LoJdevB192LIvhRLaNBDIJXehlcexFlvaauyW_Ptqs5slLYWcNGKeeefjLYr3HFYcZPPZ04SblQAuVkq-Kk65rnippYbXx7gWJ8U7og1Apetavy1OhKiFkKo9Lbrr4BJawo4ldLMd2eRdimufo-TdEJCIeWKWKDpv58z99vPA5gHZNiFhcMhiz1wc40HAdhjiZHNZYMMy2UDnxZvejoQXh_esuPv-7e7yR3lze3V9-fWmdKrRc-kq0MI60Kpadx202Lv80S00FhRUrlI9B4C26qxV2GgA0cheua7lwPtanhVf9rLbZT1h5zDMyY5mm_xk04OJ1pu_M8EP5j7-MlKpuuEiC3w6CKT4c0GazeTJ4TjagHEhw4XgXEFbty-jeQtdy0rJjH78B93EJYV8iEwpaKTm7W74ck_l6xMl7I9zczA7p82j02bntHlU_fB82SP9ZG0GVnuAcircY3re9n-KfwDQWrU7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1040837196</pqid></control><display><type>article</type><title>Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans</title><source>Oxford Journals Open Access Collection</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Sanapareddy, Nina ; Legge, Ryan M ; Jovov, Biljana ; McCoy, Amber ; Burcal, Lauren ; Araujo-Perez, Felix ; Randall, Thomas A ; Galanko, Joseph ; Benson, Andrew ; Sandler, Robert S ; Rawls, John F ; Abdo, Zaid ; Fodor, Anthony A ; Keku, Temitope O</creator><creatorcontrib>Sanapareddy, Nina ; Legge, Ryan M ; Jovov, Biljana ; McCoy, Amber ; Burcal, Lauren ; Araujo-Perez, Felix ; Randall, Thomas A ; Galanko, Joseph ; Benson, Andrew ; Sandler, Robert S ; Rawls, John F ; Abdo, Zaid ; Fodor, Anthony A ; Keku, Temitope O</creatorcontrib><description>Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.</description><identifier>ISSN: 1751-7362</identifier><identifier>EISSN: 1751-7370</identifier><identifier>DOI: 10.1038/ismej.2012.43</identifier><identifier>PMID: 22622349</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/2565/855 ; 692/698/2741/2135 ; 692/699/67/1504/1885 ; 692/700/139 ; Adenoma ; Adenoma - microbiology ; Adenoma - pathology ; Bacteria - classification ; Bacteria - genetics ; Biomedical and Life Sciences ; Biopsy ; Case-Control Studies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - microbiology ; Colorectal Neoplasms - pathology ; Crohn's disease ; Diets ; Digestive tract ; DNA, Bacterial - genetics ; Ecology ; Evolutionary Biology ; Female ; Genetics ; Humans ; Life Sciences ; Male ; Metagenome ; Microbial Ecology ; Microbial Genetics and Genomics ; Microbiology ; Middle Aged ; Mucosa ; Obesity ; Original ; original-article ; Rectum ; Rectum - microbiology ; Rectum - pathology ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Sequence Analysis, DNA ; Titanium ; Ulcerative colitis</subject><ispartof>The ISME Journal, 2012-10, Vol.6 (10), p.1858-1868</ispartof><rights>International Society for Microbial Ecology 2012</rights><rights>Copyright Nature Publishing Group Oct 2012</rights><rights>Copyright © 2012 International Society for Microbial Ecology 2012 International Society for Microbial Ecology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-c5072ac0745bdd09efcc077908a0405c54f100095daa4e8700283f4cd9101f63</citedby><cites>FETCH-LOGICAL-c487t-c5072ac0745bdd09efcc077908a0405c54f100095daa4e8700283f4cd9101f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446812/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446812/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22622349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanapareddy, Nina</creatorcontrib><creatorcontrib>Legge, Ryan M</creatorcontrib><creatorcontrib>Jovov, Biljana</creatorcontrib><creatorcontrib>McCoy, Amber</creatorcontrib><creatorcontrib>Burcal, Lauren</creatorcontrib><creatorcontrib>Araujo-Perez, Felix</creatorcontrib><creatorcontrib>Randall, Thomas A</creatorcontrib><creatorcontrib>Galanko, Joseph</creatorcontrib><creatorcontrib>Benson, Andrew</creatorcontrib><creatorcontrib>Sandler, Robert S</creatorcontrib><creatorcontrib>Rawls, John F</creatorcontrib><creatorcontrib>Abdo, Zaid</creatorcontrib><creatorcontrib>Fodor, Anthony A</creatorcontrib><creatorcontrib>Keku, Temitope O</creatorcontrib><title>Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans</title><title>The ISME Journal</title><addtitle>ISME J</addtitle><addtitle>ISME J</addtitle><description>Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.</description><subject>631/326/2565/855</subject><subject>692/698/2741/2135</subject><subject>692/699/67/1504/1885</subject><subject>692/700/139</subject><subject>Adenoma</subject><subject>Adenoma - microbiology</subject><subject>Adenoma - pathology</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Crohn's disease</subject><subject>Diets</subject><subject>Digestive tract</subject><subject>DNA, Bacterial - genetics</subject><subject>Ecology</subject><subject>Evolutionary Biology</subject><subject>Female</subject><subject>Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metagenome</subject><subject>Microbial Ecology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Obesity</subject><subject>Original</subject><subject>original-article</subject><subject>Rectum</subject><subject>Rectum - microbiology</subject><subject>Rectum - pathology</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Sequence Analysis, DNA</subject><subject>Titanium</subject><subject>Ulcerative colitis</subject><issn>1751-7362</issn><issn>1751-7370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1r3DAQhk1padIkx16LoJdevB192LIvhRLaNBDIJXehlcexFlvaauyW_Ptqs5slLYWcNGKeeefjLYr3HFYcZPPZ04SblQAuVkq-Kk65rnippYbXx7gWJ8U7og1Apetavy1OhKiFkKo9Lbrr4BJawo4ldLMd2eRdimufo-TdEJCIeWKWKDpv58z99vPA5gHZNiFhcMhiz1wc40HAdhjiZHNZYMMy2UDnxZvejoQXh_esuPv-7e7yR3lze3V9-fWmdKrRc-kq0MI60Kpadx202Lv80S00FhRUrlI9B4C26qxV2GgA0cheua7lwPtanhVf9rLbZT1h5zDMyY5mm_xk04OJ1pu_M8EP5j7-MlKpuuEiC3w6CKT4c0GazeTJ4TjagHEhw4XgXEFbty-jeQtdy0rJjH78B93EJYV8iEwpaKTm7W74ck_l6xMl7I9zczA7p82j02bntHlU_fB82SP9ZG0GVnuAcircY3re9n-KfwDQWrU7</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Sanapareddy, Nina</creator><creator>Legge, Ryan M</creator><creator>Jovov, Biljana</creator><creator>McCoy, Amber</creator><creator>Burcal, Lauren</creator><creator>Araujo-Perez, Felix</creator><creator>Randall, Thomas A</creator><creator>Galanko, Joseph</creator><creator>Benson, Andrew</creator><creator>Sandler, Robert S</creator><creator>Rawls, John F</creator><creator>Abdo, Zaid</creator><creator>Fodor, Anthony A</creator><creator>Keku, Temitope O</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans</title><author>Sanapareddy, Nina ; Legge, Ryan M ; Jovov, Biljana ; McCoy, Amber ; Burcal, Lauren ; Araujo-Perez, Felix ; Randall, Thomas A ; Galanko, Joseph ; Benson, Andrew ; Sandler, Robert S ; Rawls, John F ; Abdo, Zaid ; Fodor, Anthony A ; Keku, Temitope O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-c5072ac0745bdd09efcc077908a0405c54f100095daa4e8700283f4cd9101f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/326/2565/855</topic><topic>692/698/2741/2135</topic><topic>692/699/67/1504/1885</topic><topic>692/700/139</topic><topic>Adenoma</topic><topic>Adenoma - microbiology</topic><topic>Adenoma - pathology</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - microbiology</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Crohn's disease</topic><topic>Diets</topic><topic>Digestive tract</topic><topic>DNA, Bacterial - genetics</topic><topic>Ecology</topic><topic>Evolutionary Biology</topic><topic>Female</topic><topic>Genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metagenome</topic><topic>Microbial Ecology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Obesity</topic><topic>Original</topic><topic>original-article</topic><topic>Rectum</topic><topic>Rectum - microbiology</topic><topic>Rectum - pathology</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><topic>Sequence Analysis, DNA</topic><topic>Titanium</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanapareddy, Nina</creatorcontrib><creatorcontrib>Legge, Ryan M</creatorcontrib><creatorcontrib>Jovov, Biljana</creatorcontrib><creatorcontrib>McCoy, Amber</creatorcontrib><creatorcontrib>Burcal, Lauren</creatorcontrib><creatorcontrib>Araujo-Perez, Felix</creatorcontrib><creatorcontrib>Randall, Thomas A</creatorcontrib><creatorcontrib>Galanko, Joseph</creatorcontrib><creatorcontrib>Benson, Andrew</creatorcontrib><creatorcontrib>Sandler, Robert S</creatorcontrib><creatorcontrib>Rawls, John F</creatorcontrib><creatorcontrib>Abdo, Zaid</creatorcontrib><creatorcontrib>Fodor, Anthony A</creatorcontrib><creatorcontrib>Keku, Temitope O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The ISME Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanapareddy, Nina</au><au>Legge, Ryan M</au><au>Jovov, Biljana</au><au>McCoy, Amber</au><au>Burcal, Lauren</au><au>Araujo-Perez, Felix</au><au>Randall, Thomas A</au><au>Galanko, Joseph</au><au>Benson, Andrew</au><au>Sandler, Robert S</au><au>Rawls, John F</au><au>Abdo, Zaid</au><au>Fodor, Anthony A</au><au>Keku, Temitope O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans</atitle><jtitle>The ISME Journal</jtitle><stitle>ISME J</stitle><addtitle>ISME J</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>6</volume><issue>10</issue><spage>1858</spage><epage>1868</epage><pages>1858-1868</pages><issn>1751-7362</issn><eissn>1751-7370</eissn><abstract>Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22622349</pmid><doi>10.1038/ismej.2012.43</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1751-7362 |
| ispartof | The ISME Journal, 2012-10, Vol.6 (10), p.1858-1868 |
| issn | 1751-7362 1751-7370 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3446812 |
| source | Oxford Journals Open Access Collection; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 631/326/2565/855 692/698/2741/2135 692/699/67/1504/1885 692/700/139 Adenoma Adenoma - microbiology Adenoma - pathology Bacteria - classification Bacteria - genetics Biomedical and Life Sciences Biopsy Case-Control Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - microbiology Colorectal Neoplasms - pathology Crohn's disease Diets Digestive tract DNA, Bacterial - genetics Ecology Evolutionary Biology Female Genetics Humans Life Sciences Male Metagenome Microbial Ecology Microbial Genetics and Genomics Microbiology Middle Aged Mucosa Obesity Original original-article Rectum Rectum - microbiology Rectum - pathology RNA, Ribosomal, 16S - genetics rRNA 16S Sequence Analysis, DNA Titanium Ulcerative colitis |
| title | Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T17%3A59%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20rectal%20microbial%20richness%20is%20associated%20with%20the%20presence%20of%20colorectal%20adenomas%20in%20humans&rft.jtitle=The%20ISME%20Journal&rft.au=Sanapareddy,%20Nina&rft.date=2012-10-01&rft.volume=6&rft.issue=10&rft.spage=1858&rft.epage=1868&rft.pages=1858-1868&rft.issn=1751-7362&rft.eissn=1751-7370&rft_id=info:doi/10.1038/ismej.2012.43&rft_dat=%3Cproquest_pubme%3E1221140969%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1040837196&rft_id=info:pmid/22622349&rfr_iscdi=true |